A Physiological Review on Dhatu Kshaya Vriddhi in Ayurveda and Modern Perspective

Saptadhatus are produced in a manner akin to a progressive evolutionary metamorphosis, starting with Rasa Dhatu (primary product of digested food), continuing with Rakta (blood tissue), Mamsa (muscle tissue), Meda (fat tissue), Asthi (bone tissue), Majja (bone marrow), and ending with Sukra Dhatu (reproductive fluids). Each Dhatu feeds the one above it, and they serve as the foundation for each. The meal maintains equilibrium among the continuously dwindling Dhatus . This indicates that the Dhatus are interconnected, with changes in one leading to changes in the other. This review's objective is to combine various sources and reach a shared understanding. The article offers a thorough understanding of the term Dhatu-kshaya or depletion and Dhatu vriddhi or growth.

➢ Mamsa, which protects the sensitive internal organs; allows for joint and bone flexibility and keepsthe body's physical prowess and potential.➢ Meda Dhatu preserves tissues' oiliness and offers muscle mass, compactness, and prevention body from external and environmental harm.➢ Asthi Dhatu gives the body stability and gives foundation and framework for the body.This Dhatu is with Sandhi is in charge of mobility as well sustain the body.➢ Majja fills up bone gaps and creates more Dhatus.➢ Shukra is related to reproductive health and sexual prowess, which helped with the particular Gender function is responsible for fertilization and produces healthy offspring if operating in right way

RAS DHATU KSHAYA LAKSHANA
The Rasa is the first tissue to develop as a result of food digestion.It's been compared to blood plasma by some.Kapha Dosha and Rasa Dhatu are intimately related.Rasa Dhatu is directly impacted by changes in the Kapha Dosha.Dehydration and a lack of nutrients are indicated by a decrease in Rasa Dhatu. 10 The symptoms include: Ghattate (restlessness in the patient ); Sahate Shabdam Na (he develops intollerance against loud noises) ; Hrudrava (palpitations), HrudayamTamyatiAlpaCheshtasyaApi causes cardiac pain, and fatigue even after minimal effort.

MAJJA DHATU VRIDDHI LAKSHANA
Increased Majja (marrow) results in weightiness in the body and eyes, enlargement of the joints in the body, and ulcers that are challenging to treat.

CONCLUSION AND DISCUSSION
The Saptadhatu theory of Ayurveda describes seven bodily tissues that provide the body's structural framework and support.Seven Dhatus were listed in Ayurveda's Rasa, Rakta, Mamsa, Meda, Asthi, Majja and Shukra.According to Ayurveda, the nutrients of Ahara first provide to the plasma (Rasa Dhatu) power, which then nourishes other tissues.Both the excess and depletions of Dhatus result in physiological activity is out of equilibrium.
Dhatu each have its own systems (srotas).The vitiation of Dosha affects these Srotas, which results in illnesses.Dhatu serve as both the diagnosis' site of lesion and the treatment's target receptors.In order to diagnose a certain condition, the Dhatu growth or reduction is also evaluated.The vitiated Dosha is located in the Dhatu and manifests as particular clinical symptoms .The participation of a certain Dhatu is significant when considering prognosis.
Astringency in body parts, expansion of the upper and lateral sides, poor breath, an unpleasant odor emanating from the body, and other symptoms are brought on by an increase in Meda Dhatu.aswell as exhaustion, breathing problems even after light activity, and sagging of the buttocks, breasts, and belly.
15creased muscle tissue results in Ganda(cervical lymphadenitis); Granthi (tumor); Cheek, thigh, and abdominal development as well as excessive neck and other muscular growth MEDO DHATU KSHAYA LAKSHANA Mamsa Dhatu gives nutrition to fat tissue.A deficiency of this results in bodily thinning, Sandhi Sphutana( joint cracking), Glani (Lassitude ), AkshnoAyasa (eyes that are fatigued ) Udara Tanutva, or abdominal thinness, 13MEDO DHATU VRUDDHI LAKSHANA ASTHI DHATU KSHAYA LAKSHANAVata Dosha and bone tissue have an inverse relationship.This shows that loss of bone tissue and an increase in Vata Dosha are correlated.According to Ayurveda, bone tissue is associated to teeth, nails, and mustaches.Therefore, bone tissue loss symptoms as Kesha, Loma, Nakha, Shmashru, and Dvijaprapatana (hair loss, loss of nails and beard hair, including teeth and moustaches) Shrama (fatigue) Sandhi shaithilya (loose joints).14ASTHIDHATUVRIDDHILAKSHANAThesigns of Asthi Vriddhi are Adhyasthi (extra pointed bone development over bone or calcification) and Adhidanta (growing of additional teeth or hyperdontia).15MAJJADHATUKSHAYA LAKSHANA According to Ayurveda, Asthi Dhatu feeds the marrow.Depletion of the Majja Dhatu results in the following effects on the bones: AsthiSheeryata, Durbala, and Laghu Asthi( bones being empty, weak, and light), VataRoga (a condition marked by vata imbalance issues).16