Effect of Shadangapaniya in Various Systems: A Review

Ayurveda has mentioned many kalpanas one among them is Paniya kalpana. It comes under Upakalapana of Kwatha . It is regarded as the most beneficial and potent because it is very easy to digest and readily absorbed by bodies. Agni is most important component and govern its healthy and unhealthy status. In a healthy state, Sharira maintains regular physiological functioning; when it is impaired, Sharira results in various ailments. Shadangapaniya is a special formulation that controls all the aforementioned aspects. Six herbs, including Musta , Parpataka , Ushira , Chandana , Udichya , and Nagara , make up the Shadangapaniya ,it acts on the various physiological systems like Nervous system,Respiratory system, Digestive system etc.,


INTRODUCTION
Plants have long been an essential source of natural products for human health, as well as the cheapest and safest forms of treatment for various disorders.Plant-based medications are high in health-promoting and therapeutic properties.Infectious diseases are the leading cause of death and morbidity, and they are a serious public health concern due to poor antibiotic use and bacterial resistance.Ayurveda is a medical healthcare system that is practiced around the world, particularly in South East Asian countries.Shadangapaniya is a well-known Ayurvedic treatment for it.It alleviates excessive thirst, sweat, and a burning sensation.It is an aqueous decoction of a polyherbal preparation containing six herbs in equal parts.It is used in Pittashamaka therapy and is recommended in Jwar Roga.Each herb has its own scientific justification, but combining six herbs is give excellent results in various ailments.

IJFMR240111874
Volume 6, Issue 1, January-February 2024 2  Therefore, it may be able to increase cerebral blood flow, which would improve both attention and the capability of cognitive processing as well as spatial memory.

Digestive system:
Hydro-alcoholic S. album stem extract has been shown to have gastroprotective properties and to treat stomach aches and upset stomachs.Sandalwood's potent antiviral and antibacterial qualities fight helicobacter pylori, which results in ulcers and gastrointestinal problems.It also protects the liver.x • Dry ginger has been researched for its gastrointestinal system protection as an extension of its antiemetic activity.The impact of ginger on stomach function, particularly in reference to dysrhythmia and gastric emptying.According to a study, ginger therapy greatly decreased the tachygastric activity brought on by circular vection, a condition that causes one to feel as though they are rotating without actually moving.Sunthi is helpful in treating motion sickness, morning sickness, nausea, and vomiting.• It resulted in significant symptom relief and simultaneous blood sugar level normalization.bowel habits regulation, overall health enhancement, including anaemia and body weight gain, and gastrointestinal function enhancement.• Sunthi, which has a pungent flavor, is renowned for treating nausea and upset stomache.It is used for a variety of conditions that restrict gastric secretions and aid in preventing nausea and vomiting during upset stomachs and pregnancy.It contains several substances that function as antipyretics, analgesics, and antitussives.• The herb Sunthi is incredibly beneficial.In the long run, it can help treat conditions like arthritis in addition to reducing inflammation.The herb can be used to treat digestive disorders as well because it is so effective for abdominal issues.It aids in proper digestion by breaking down the proteins.Additionally, it treats infants' diarrhea by halting bacterial growth.It is referred to as "universal herb" due to its wide range of therapeutic benefits.• Its curing properties also keep the intestinal muscles toned.Sunthi can be used to treat inflammatory diseases like arthritis since it reduces inflammation.It aids in the breakdown of proteins and the digestion of fats.Additionally, it helps to lessen belly gaseous distension.An anti-diarrheal According to reports, Sunthi slows down bacterial metabolism, which inhibits the creation of toxins and controls infectious diarrhea.• The herb Fumaria plaviflora has been used to improve digestion and relieve symptoms like indigestion and gas.• Pavonia odorata has been used to treat stomach discomfort in several traditional practices.It can be used to promote healthy digestion, reduce indigestion, and ease stomach aches.• Antidiarrheal effects indicate that C. rotundus has only weak antibacterial and antirotavirus effects.
The antidiarrheal effects of Musta are probably brought about by its impact on a bacterial virulence factor like colonization.

Respiratory system
• Dry ginger's expectorant and warming properties aid in the relief of cough and cold symptoms, as well as respiratory discomfort and congestion.It has an antiasthmatic nature.• Following an allergic reaction, the anti-allergic impact produces degranulation, which releases histamine and -hexosaminidase.Ushira is a medication that is used to treat bronchial asthma, hiccups, and coughing.It is also beneficial in cases of tuberculosis-induced hemoptysis.• Musta is useful for treating respiratory disorders caused by gastrointestinal disease.
• Sandalwood is beneficial in hemoptysis and purulent expectoration.Bad breath ultimately fades.
• Pavonia odorata has been used in several traditional medical practices to treat respiratory disorders.
Because it is known to have expectorant properties, it may be used to relieve coughs and congestion.

Skin
• Sandalwood oil is incredibly effective at treating a variety of skin problems, including dryness, popping, chipping, and wrinkles.Enhancing skin tone, preserving skin radiance, and helping to regenerate damaged skin cells are all benefits of sandalwood oil.As an astringent, cleanser, antibacterial, anti-aging, and sanitizer, sandalwood oil defends the skin from damaging germs, infections, and parasite attacks.Cuts, bruises, scars, pimples, and other skin disorders can be treated topically by using sandalwood oil on the affected area.• Parpataka has been used in conventional therapies for eczema, acne, and rashes.Its anti-inflammatory and detoxifying properties are thought to contribute to these outcomes.• Pavonia odorata can be used to soothe skin irritations and treat wounds due to its potential antiinflammatory and wound-healing properties.• Email: editor@ijfmr.comIJFMR240111874 Volume 6, Issue 1, January-February 2024 5

Cardiovascular Health:
• Ginger may benefit cardiovascular health by contributing in blood pressure lowering and blood circulation improvement.Its antioxidant properties may also be advantageous for heart health.• Tikta Rasa is a blood purifier because it is so common.It reduces the excessive water content of blood.
It safeguards hemostasis and the heart.It alleviates epistaxis.It can help with diaphoresis, which is excessive sweating brought on by a secondary ailment.

Antiplatelet activity
By blocking platelet aggregation, Musta demonstrated antiplatelet activity.Additional validation of this came from in vivo studies revealing effects on the lengthening of bleeding time in rats.In vivo tests on various compounds revealed that Nootkatone in particular could prolong bleeding time and reduce platelet aggregation.Nootkatone and the extract in general, which inhibits platelet aggregation and may be useful for treating atherothrombotic diseases, have been the subject of studies.xi

Wound healing activity
Analyzed the ability of the Cyperus rotundus tuber extract to cure wounds.Based on its historical use and literary connections, this plant was selected for study of its capacity to heal wounds.An alcoholic extract of tuber sections of Cyperus rotundus was investigated for its ability to promote wound healing in three distinct rat wound models, including excision, incision, and dead space wound models.The extract ointments have shown a notable difference in response in all of the aforementioned wound models, as comparable to those of a conventional pharmaceutical nitrofurazone ointment in terms of wound contracting ability, wound closure duration, and tensile strength.xii

Antioxidant activity
The antioxidant activity of Cyperus rotundus rhizomes extract (CRRE) was assessed using a variety of in vitro tests including free radicals and reactive oxygen species, and IC50 values were computed.CRRE proved its scavenging function in a concentration-dependent manner on superoxide anion radicals, hydroxyl radicals, nitric oxide radicals, hydrogen peroxide, and the property of metal chelating and reducing power.Thiobarbituric acid-reactive substances (TBARS) and young and aged rat brain mitochondria were used to further examine the extract for lipid peroxidation.Additionally, the extract showed concentration-dependent effectiveness in decreasing FeSO4 ascorbate-induced mitochondrial lipid peroxidation.According to this study's findings, C. rotundus rhizome extract may include natural antioxidants.xiii

CONCLUSION:
Shadangapaniya is a distinctive and popular recipe that preserves state of equilibrium.Additionally, it clears Ama Visha and is the best remedy for detoxification of toxins.There is action of individual's herbs but Shadangapaniya is amalgamated on heating with water.There are six medicinal component enhances the activity of various system towards homeostasis state.
• Cyprus extract possesses significant CNS depressive, neuroprotective, and nervine tonic effects.Excitotoxicity, oxidative stress, neurological development, and neurodegeneration prevention therapy all exhibited significant benefits.• Ushira and Musta are nervine tonics.Musta is used to treat convulsions and brain injury in conjunction with milk paste .Pentylenete-trazole and electroshock were utilized in a pre-clinical experiment to induce convulsions, and the Mustaka ethonolic extract produced positive results.The results showed that the flavonoids contained in the ethanol extract of Cyprus rotundus rhizomes are important for treating epilepsy and have anticonvulsant effect.The Cyprus extract has potent CNS depressive, neuroprotective, and nervine tonic properties.Excitotoxicity, oxidative stress, neurological development, and preventive therapy for neurodegeneration all saw considerable improvements.viii • Ushira and Musta are nervine tonics.Musta is used to treat convulsions and brain injury in conjunction with milk paste.Pentylenete-trazole and electroshock were utilized in a pre-clinical experiment to induce convulsions, and the Mustaka ethonolic extract produced positive results.The results showed that the flavonoids contained in the ethanol extract of Cyprus rotundus rhizomes are important for treating epilepsy and have anticonvulsant effect.• Rakta Chandan has been shown to help with epilepsy, hysteria, and even Parkinson's disease.It also aids in the reduction of accumulated tension and anxiety.ix • Effects of Nagara on memory loss.Additionally, it lessened the cognitive impairment brought on by focal cerebral ischemia.It can boost the number of neurons in the brain's hippocampus and enhance spatial memory.It has been noted to cause vasodilation in the past.