International Journal For Multidisciplinary Research

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Association of Serum Vitamin D Level with Gestational Hypertension and Preeclampsia in Pregnant Women: A Case-Control Study

Author(s) Dr. Minara Parvin, Dr. Md. Ashiq Iqbal
Country Bangladesh
Abstract Abstract
Background: Vitamin D status has been increasingly associated with wide-ranging clinical outcomes. There is now a wealth of observational studies reporting on its association with obstetric complications, including gestational hypertension, preeclampsia and gestational diabetes. So we did a case control study to see the Vitamin D Levels in pregnant Women with gestational HTN and preeclampsia which are compared to age and gestational age-matched healthy pregnant controls. This study was conducted at Department of Obstetrics and Gynecology, Dinajpur medical college Hospital, Dinajpur.
Objectives: To see the association of serum vitamin D level with gestational HTN and preeclampsia.
Material and methods: This was a hospital- based observational case control study carried out in Dep. of Obstetrics and Dinajpur medical college Hospital for a period of 6 months. Consecutive, convenient sampling was done. 100 pregnant Women with gestational HTN and preeclampsia fulfilling inclusion and exclusion criteria was included in the study.100 age and gestational age matched healthy pregnant controls was included in the study attending at outpatient department. Serum vit D level was measured of all subjects and data was analyzed to find out the association of vit D level with gestational HTN and preeclampsia.
Results: Our study found significant relationship of serum vit D level with gestational HTN & preeclampsia. After doing statistical analysis we found P value was 0.043 which is statistically significant. Among all the subjects, mean values of serum vitamin D levels in study group and control group were 13.83 ± 7.41 ng/ml and 18.86 ± 5.88 ng/ml respectively. Our study population had a very high prevalence of vitamin D deficiency (<20 ng/ml). Among all the subjects, 77.50 % had serum 25(OH)D levels <20 ng/ml reflecting widespread vit D deficiency in all pregnant women. We observed that 86% of the case and 69% of the control were vitamin D deficient with a odds ratio 2.76 (OR>1) which is a positive association.
Conclusion:
Our study found very high prevalence of vitamin D deficiency (75.50 %). We found that. Risk of developing gestational HTN and preeclampsia rises with vitamin D deficiency.
Keywords Vitamin D, Hypertension in pregnancy, Preeclampsia, Gestational hypertension, 25(OH)D
Field Medical / Pharmacy
Published In Volume 7, Issue 6, November-December 2025
Published On 2025-11-22
DOI https://doi.org/10.36948/ijfmr.2025.v07i06.58051
Short DOI https://doi.org/hbb78r
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