International Journal For Multidisciplinary Research

E-ISSN: 2582-2160     Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 6 Issue 2 March-April 2024 Submit your research before last 3 days of April to publish your research paper in the issue of March-April.

Validation of RP-HPLC Method for the Estimation of Timolol Maleate in Fast Dissolving Tablets

Author(s) Gurpreet Singh, R.K Dhawan
Country India
Abstract A simple, precise and reproducible validation method was develop for Timolol Maleate as per ICH (International Council for Harmonization) guidelines Q2R(1) and subsequently stability indicating method as per ICH guidelines Q1A(R2). Chromatographic evaluation was carried out on C18 column of Agilent (25 cm x 4.6 mm), (i.d. 5 µm.) with a mobile phase consist of Methanol : Water (20:80 v/v). Flowrate was maintained to 0.8ml/min. The stability indicating data revealed that Timolol Maleate was found to be unstable alkaline condition. The validated method was applied various validation parameters like Linearity(calibrationcurve),Precision, Accuracy,Robustness,LOD and LOQ were found to be 0.9μg/ml and 2μg/ml. The validated method can be used for estimation of Timolol Maleate in prepared Fast DissolvingTablets (FDTs) by using Croscar mellose Sodium(CCS) as a superdisintegrant a calculated their optical parameters.
Keywords Timolol Maleate, RP-HPLC, Stability Studies, FDTs
Field Chemistry > Pharmacy
Published In Volume 6, Issue 2, March-April 2024
Published On 2024-03-09
Cite This Validation of RP-HPLC Method for the Estimation of Timolol Maleate in Fast Dissolving Tablets - Gurpreet Singh, R.K Dhawan - IJFMR Volume 6, Issue 2, March-April 2024. DOI 10.36948/ijfmr.2024.v06i02.13862
DOI https://doi.org/10.36948/ijfmr.2024.v06i02.13862
Short DOI https://doi.org/gtmbk7

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