International Journal For Multidisciplinary Research

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Evaluation of Anti Ulcer Activity of Methanolic Leaf Extract of Jacquemontia Caerulea Against Experimentally Induced Ulcers in Wistar Rats

Author(s) Adiba Afreen, Shaik Mohd Khasim, Tabrez Abdullah, Noorunnisa Begum
Country India
Abstract Objective: To evaluate the anti-ulcerogenic effect of Jacquemontia caerulea Leaf Methanolic Extract (JCLME) against aspirin, ethanol, cold stress induced and pylorus ligation induced gastric ulcers in Wistar rats.
Methods: The methanolic extract of fresh leaves of the plant, Jacquemontia caerulea (Family Convolvulaceae) was prepared and assessed for anti-ulcer effect with different doses and the standard drugs (Risperidone and Amitriptyline respectively) by using aspirin, ethanol, cold stress induced and pylorus ligation methods.
Results: JCLME was assessed and compared statistically with the anti-ulcer effects in the control rats which was treated with saline (NaCl, 0.9%). It was found that JCLME at doses of 200 and 400 mg/kg reduced the ulcer index significantly when compared to control group (p< 0.05). It was found that JCLME
significantly reduced the free acidity, total acidity and ulcer index (p<0.05) and increased the gastric content when compared with the control group. Hence, the current study shows that the JCLME has potent anti-ulcer, cytoprotective and antisecretory property thereby making it a great ulcero-protective agent.
Keywords Jacquemontia caerulea, Methanol, aspirin, Misoprostol, Ethanol, Pylorus ligation, Anti ulcer activity.
Field Medical / Pharmacy
Published In Volume 6, Issue 1, January-February 2024
Published On 2024-02-29
DOI https://doi.org/10.36948/ijfmr.2024.v06i01.14236
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