International Journal For Multidisciplinary Research

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A Research Work on Design, Development and In-Vitro Evaluation of Losartan Potassium Loaded Pectinate Microspheres

Author(s) Bishan Sarkar, Sourav Mandal, Tuhin Sarkar, Suchetan Sarkar
Country India
Abstract One of the special and innovative drug delivery strategies is the use of microspheres, which can increase a drug's effectiveness by preventing drug dilution in bodily fluids, allowing drug localization and targeting at a specific site, and maintaining drug concentration between MEC and MTC levels.Microspheres are characterized as roughly spherical, solid particles with sizes between 1 to 1000 μm that are intended to be covered in protective materials such as polymeric or waxy coatings. One of the more innovative methods in the field of oral controlled drug delivery systems is the use of microsphere dosage forms, which target a specific area of the body for a prolonged period of time, allowing for more effective local drug delivery as well as improved systemic drug. The % yield of all the losartan potassium loaded pectinate microsphere formulations (LM1 to LM5) was found within the range from 76.74 ± 3.79 % to 89.06 ± 2.67 %.The % entrapment efficiency and particle size of the prepared losartan potassium loaded pectinate microsphere formulations (LM1 to LM5) was found within the range from 63.68 ± 3.55 % to 84.78 ± 2.27 % and 0.78 ± 0.14 mm to 0.91 ± 0.05 mm respectively. Formulations LM1 to LM5 showed 2.12 % to 12.46 % mucoadhesion up to 6 hours in simulated gastric fluid (pH 1.2, 0.1N HCl) and 74.28 % to 96.04 % mucoadhesion up to 6 hours in simulated intestinal fluid (phosphate buffer, pH 6.8).
Keywords Losartan Potassium, Pectinate Microspheres, NDDS
Field Medical / Pharmacy
Published In Volume 6, Issue 2, March-April 2024
Published On 2024-03-20
Cite This A Research Work on Design, Development and In-Vitro Evaluation of Losartan Potassium Loaded Pectinate Microspheres - Bishan Sarkar, Sourav Mandal, Tuhin Sarkar, Suchetan Sarkar - IJFMR Volume 6, Issue 2, March-April 2024. DOI 10.36948/ijfmr.2024.v06i02.15156
DOI https://doi.org/10.36948/ijfmr.2024.v06i02.15156
Short DOI https://doi.org/gtnkbq
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