Formulation and Evaluation of Diclofenac Transdermal Gel

Author(s)	Prerana Sahu, Varsha Choudhary, Dr Gyanesh Sahu, Dr Harish Sharma
Country	India
Abstract	Diclofenac sodium gel is a widely used nonsteroidal anti-inflammatory drug (NSAID) formulation designed for topical application, primarily targeting local pain and inflammation. This wok aims to provide a comprehensive analysis of the anti-inflammatory activity of diclofenac sodium gel, focusing on its mechanism of action, efficacy, safety profile, and clinical applications. Several clinical studies have investigated the efficacy of diclofenac sodium gel in various inflammatory conditions, including osteoarthritis, rheumatoid arthritis, and soft tissue injuries. Results consistently demonstrate significant reductions in pain, swelling, and functional impairment, validating the gel's anti-inflammatory properties. The safety profile of diclofenac sodium gel is generally favorable, with local skin reactions being the most commonly reported adverse events. Systemic absorption is low, reducing the risk of gastrointestinal complications and other systemic side effects associated with oral NSAIDs. However, caution should be exercised in individuals with a history of hypersensitivity reactions or skin disorders.
Keywords	Inflammation, anti-inflammatory, diclofenac sodium, NSAID
Field	Medical / Pharmacy
Published In	Volume 6, Issue 2, March-April 2024
Published On	2024-04-11
DOI	https://doi.org/10.36948/ijfmr.2024.v06i02.17023

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