International Journal For Multidisciplinary Research

E-ISSN: 2582-2160     Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 6 Issue 3 May-June 2024 Submit your research before last 3 days of June to publish your research paper in the issue of May-June.

A Journey through Huntington's Disease: Exploring Genetics, Neurobiology, and Therapeutic Advances

Author(s) Sandeep Dey, Shreyas Katta, Saigayathri Suresh, Janhvi Mishra
Country India
Abstract Huntington disease (HD) is a progressive neurodegenerative disease that is debilitating for families worldwide. Inherited in an autosomal dominant manner, HD results from a CAG expansion in the gene encoding the huntingtin protein. This mutation leads to a host of motor, cognitive, and psychiatric symptoms that generally appear in middle age. While spiny projection neurons in the striatum are the most vulnerable cell type in HD, notable atrophy occurs throughout the brain, including the white matter; for this reason, HD is now considered to be a brain-wide disease. The clinical features, ethics, and neurobiology of HD are discussed in this chapter. The chapter also reviews the exciting approaches being employed today to advance understanding of underlying mechanisms in an effort to develop therapies that would delay the onset and slow progression of this disease.
Field Medical / Pharmacy
Published In Volume 6, Issue 3, May-June 2024
Published On 2024-05-05
Cite This A Journey through Huntington's Disease: Exploring Genetics, Neurobiology, and Therapeutic Advances - Sandeep Dey, Shreyas Katta, Saigayathri Suresh, Janhvi Mishra - IJFMR Volume 6, Issue 3, May-June 2024. DOI 10.36948/ijfmr.2024.v06i03.19194
DOI https://doi.org/10.36948/ijfmr.2024.v06i03.19194
Short DOI https://doi.org/gttbhs

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