International Journal For Multidisciplinary Research

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Role of Autologous Platelet Rich Plasma in the Management of Chronic Non Healing Ulcers

Author(s) M. Akhila, Vuribindi Manognitha Reddy, Archana Chilakala, Lakshmi Meena Jasti, Sunku Thirupathi
Country India
Abstract Background: Chronic non-healing leg ulcers are a major health problem worldwide and have great impact on personal, professional and social levels, with high cost in terms of human and material resources. The present study was conducted with an aim to demonstrate the efficacy of autologous platelet rich plasma (PRP) in chronic non-healing leg ulcers in comparison to conventional dressings.

Methods: About 50 patients presenting with chronic non healing ulcers to the surgical outpatient department in a tertiary care centre over a period of one year were included in the study, of which 25 patients received autologous PRP dressings other 25 patients received conventional dressings. Ulcer measurements were taken on day 1, 15, 28 and 42 days.

Results: The mean duration of healing of the ulcers was 3.9 weeks in PRP group and 6.2 weeks conventional dressing. PRP dressing group showed a reduction in ulcer size of about 45.50 percent as compared to 14.80 percent in conventional dressing group.

Conclusion: Chronic non healing ulcers are often difficult to heal because they lack the necessary growth factors to maintain the healing process. Conventional therapies do not provide satisfactory healing, since these treatments are not able to provide the necessary growth factors (PDGF, EGF, VGEF etc.) which are essential for the healing process. PRP is a safe, affordable, biocompatible and simple office based procedure for the treatment of non-healing ulcers.
Keywords Platelet rich plasma, PRP, leg ulcers.
Field Medical / Pharmacy
Published In Volume 5, Issue 2, March-April 2023
Published On 2023-03-19
Cite This Role of Autologous Platelet Rich Plasma in the Management of Chronic Non Healing Ulcers - M. Akhila, Vuribindi Manognitha Reddy, Archana Chilakala, Lakshmi Meena Jasti, Sunku Thirupathi - IJFMR Volume 5, Issue 2, March-April 2023. DOI 10.36948/ijfmr.2023.v05i02.1935
DOI https://doi.org/10.36948/ijfmr.2023.v05i02.1935
Short DOI https://doi.org/gr2knz
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