International Journal For Multidisciplinary Research

E-ISSN: 2582-2160     Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 6 Issue 3 May-June 2024 Submit your research before last 3 days of June to publish your research paper in the issue of May-June.

Exploring the Gut-Brain Axis: A Comprehensive Review of Interactions Between the Gut Microbiota and the Central Nervous System

Author(s) Ishaan Bakshi, Sandeep Dey, Arya J. Raut, Shreyas Katta, Prashant Sharma
Country India
Abstract The gut-brain axis represents a complex network of interactions among the gut microbiota, the enteric nervous system (ENS), the autonomic nervous system (ANS), and the central nervous system (CNS), exerting profound influences on both digestive and mental health. Dysfunction within this axis has been implicated in a spectrum of disorders ranging from irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) to depression, anxiety, and neurodegenerative conditions. While early observations of the relationship between emotions and gastrointestinal function date back to the early 20th century, recent decades have witnessed significant strides in understanding this intricate interplay, fueled by advancements in molecular biology, microbiology, and neuroscience. Key milestones include the discovery of the enteric nervous system, elucidation of gut hormone functions, and recognition of the pivotal role played by gut microbiota in shaping brain function and behavior. The gut microbiota, comprising trillions of microorganisms residing within the gastrointestinal tract, actively contribute to gut-brain communication by producing an array of metabolites, neurotransmitters, and immune modulators. This communication pathway underscores the critical importance of comprehending the intricate interplay between gut microbiota and the central nervous system for devising innovative therapeutic interventions targeting a broad spectrum of psychiatric and neurological disorders. Furthermore, lifestyle factors such as diet, stress, and antibiotic usage wield significant influence over the composition and functionality of gut microbiota, thereby emphasizing the pivotal role of lifestyle interventions in fostering and preserving gut-brain health. This abstract encapsulates the current understanding of the gut-brain axis, highlighting its multifaceted implications for health and disease management, and underscores the pressing need for continued research to unlock its therapeutic potential.
Field Medical / Pharmacy
Published In Volume 6, Issue 3, May-June 2024
Published On 2024-05-11
Cite This Exploring the Gut-Brain Axis: A Comprehensive Review of Interactions Between the Gut Microbiota and the Central Nervous System - Ishaan Bakshi, Sandeep Dey, Arya J. Raut, Shreyas Katta, Prashant Sharma - IJFMR Volume 6, Issue 3, May-June 2024. DOI 10.36948/ijfmr.2024.v06i03.19563
DOI https://doi.org/10.36948/ijfmr.2024.v06i03.19563
Short DOI https://doi.org/gttvgc

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