International Journal For Multidisciplinary Research

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HPLC Method Development and Validation for Simultaneous Estimation of Tramadol and Piroxicam

Author(s) Maninder Singh, Arvind Kumar, Mona Piplani, Pankaj Bhateja
Country India
Abstract The suggested new RP-HPLC method for the quantitative measurement of piroxicam and tramadol in bulk was found to be speedy, accurate, sensitive, straightforward, and exact. It was discovered that the pure drug's melting points for tramadol and piroxicam are between 178.42°C and 199.21° Tramadol and
Piroxicam in methanol showed a wide band at 273 nm and 334 nm in their UV spectra. The method was developed using a Force C18 Column (5 µm, 250 × 4.6 mm) at a flow rate of 1 mL/min. The optimal acetonitrile to glacial acetic acid (0.1%) ratio for the mobile phase conditions was 50:50 v/v. According to Simultaneous data, the retention length of Tramadol Amount of Acid Hydrolysis Degradation for 5 Hours at 40°C for Tramadol and Piroxicam: 3.95% and 1.40%, respectively. Tramadol and Piroxicam's base hydrolysis amount for a 5-hour period at 40°C were 7.85% and 4.77%, respectively. Quantity of Tramadol and Piroxicam's oxide degradation over a 0.5-hour period at 37°C was 17.16% and 1.28%, respectively. Tramadol and Piroxicam's UV degradation percentages after 0.5 hours are 23.72% and 0.73%, respectively. Tramadol and Piroxicam's respective amounts of thermal degradation after two hours at 105°C were 35.93% and 1.16%, respectively.
Keywords Tramadol, RP-HPLC Tramadol and Piroxicam
Field Chemistry > Pharmacy
Published In Volume 6, Issue 3, May-June 2024
Published On 2024-06-30
DOI https://doi.org/10.36948/ijfmr.2024.v06i03.23588
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