International Journal For Multidisciplinary Research

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Histomorphological Effects of Vitamin E on Doxorubicin Induced- Skeletal Muscle Toxicity in a Male Wistar Rat Model

Author(s) Ms. CHISEKWA CHIYANIKA, Careen Hankanga, Changula Katendi, Steward Mudenda, MbaweZulu, Mukape Mukape
Country Zambia
Abstract Doxorubicin-induced skeletal muscle toxicity leads to muscle atrophy, inflammation,necrosis, and fibrosis, resulting in weakness, fatigue, and impaired quality of life in cancer patients.Vitamin E has antioxidant properties that may offer protective effects, but its role in mitigatingdoxorubicin-induced muscle toxicity remains unclear.Aim: This study evaluated the histomorphological protective effects of Vitamin E againstdoxorubicin-induced skeletal muscle toxicity in male Wistar rats, focusing on anatomical cross-sectional area (ACSA), inflammation, and muscle fascicle integrity.Methods: A randomized controlled trial was conducted using 42 male Wistar rats. The maintreatment group (n = 33) was divided into three subgroups: Negative Control, Doxorubicin-only,and Doxorubicin + Vitamin E. Vitamin E was administered orally from day 1, while doxorubicinwas introduced on day 28. ACSA was measured pre- and post-treatment using high-frequencyultrasound, and tibialis anterior muscle samples were analyzed histologically. Non-parametricstatistical tests were used, with significance set at p < 0.05.Results: Significant within-group ACSA differences were observed (p < 0.005), with highbetween-group significance (p < 0.001). Inflammation scores were significantly elevated in theDoxorubicin group (p = 0.035) but reduced in the Doxorubicin + Vitamin E group (p = 0.001).Muscle fascicle integrity remained unchanged.Conclusion: This study provides significant insights into the protective role of Vitamin E againsthistomorphological changes in skeletal muscle tissue induced by Doxorubicin. The findingssuggest that Vitamin E partially mitigates muscle atrophy by preserving the anatomical cross-sectional area of the tibialis anterior muscle. Additionally, it reduces the inflammatory response,thereby improving overall tissue integrity. However, its effect on muscle fascicle distortion remainsinconclusive, indicating the need for further investigation. These results highlight the potential ofVitamin E as a therapeutic adjunct in Doxorubicin-induced skeletal muscle toxicity, warrantingadditional research on its optimal dosage and efficacy in clinical settings.
Keywords Keywords: Skeletal Muscle Toxicity, Doxorubicin, Vitamin E, Inflammation, Histoprotective
Field Medical / Pharmacy
Published In Volume 7, Issue 4, July-August 2025
Published On 2025-07-05
DOI https://doi.org/10.36948/ijfmr.2025.v07i04.38964
Short DOI https://doi.org/g9s895
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