International Journal For Multidisciplinary Research

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Buccal Drug Delivery Systems for Enhanced Management of Aphthous Ulcers: A Comprehensive Review of Formulation Strategies and Therapeutic Outcomes

Author(s) Mr. Jatin Agarwal, Mr. Mohit Saini, Mr. Akash Sharma, Mr. Hritik Goswami
Country India
Abstract Background: Buccal drug delivery systems (BDDS) present a novel approach to enhance systemic bioavailability while circumventing first-pass metabolism. This method is especially beneficial for conditions like aphthous ulcers (canker sores), which significantly impact a patient's quality of life due to their painful nature.
Objective: To evaluate the efficacy of BDDS in managing aphthous ulcers by analyzing their formulation strategies and mechanisms of drug delivery.
Aim: The aim of this study is to highlight the advantages and methodologies of BDDS in providing localized treatment for canker sores, while ensuring improved drug absorption and patient comfort.
Materials and Methodology: The review encompasses an analysis of various BDDS formulation types, including matrix and reservoir systems. It examines the mechanisms of drug permeation, focusing on transcellular and paracellular pathways. The study also assesses the role of bioadhesive polymers in prolonging drug retention and ensuring controlled release. Additionally, critical factors influencing drug effectiveness, such as pH and viscosity, are discussed alongside stability studies to evaluate long-term efficacy.
Results: The findings demonstrate that BDDS significantly enhance localized drug treatment for aphthous ulcers by utilizing bioadhesive polymers that improve retention time and controlled release. These systems effectively address discomfort and improve therapeutic outcomes.
Conclusion: BDDS represent a promising strategy for managing aphthous ulcers by facilitating targeted drug delivery and improving patient adherence. Continued advancements in formulation techniques and a better understanding of their mechanisms can lead to tailored therapeutic solutions, effectively addressing the multifactorial triggers of canker sores.
Keywords Buccal drug delivery, bioadhesive polymer, Buccal Dosage Form, Recurrent Aphthous Ulcers (RAU), Evaluation BDDS.
Field Medical / Pharmacy
Published In Volume 7, Issue 2, March-April 2025
Published On 2025-04-05
DOI https://doi.org/10.36948/ijfmr.2025.v07i02.40375
Short DOI https://doi.org/g9dgz8
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