Determinants of Success in Regenerative Endodontic Procedures: A Narrative Review

Author(s)	Dr. Mhiri Hela, Dr. Jrad Rahma, Prof. Dr. Chalbi Manel, Prof. Chemli Mohamed Ali
Country	Tunisia
Abstract	Regenerative endodontic procedures (REPs) have emerged as a biologically driven alternative to apexification in immature necrotic teeth. This narrative review synthesizes current evidence on the key factors influencing REP outcomes, including case selection, disinfection protocols, scaffold induction, and coronal sealing. Literature published between 2017 and 2024 was reviewed from PubMed and Medline, focusing on clinical studies and systematic reviews. Success is associated with minimal instrumentation, effective intracanal disinfection, induction of apical bleeding, and biocompatible sealing. Patient age, apical diameter, and procedural standardization also play critical roles. REPs, when properly indicated and executed, support root maturation and periapical healing.
Keywords	Immature permanent teeth , MTA , revitalization
Field	Medical / Pharmacy
Published In	Volume 7, Issue 2, March-April 2025
Published On	2025-04-09
DOI	https://doi.org/10.36948/ijfmr.2025.v07i02.41056
Short DOI	https://doi.org/g9fb8s

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