International Journal For Multidisciplinary Research

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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF PERINDOPRIL ERBUMINE IN BULK DRUG AND DOSAGE FORM BY UV SPECTROSCOPY

Author(s) Ms. Mitali Yuvraj Pawar, Mr. Bhagyashri Sunil Bachhav, Mr. Abhishek Sanjay Shinde, Mr. Prasad Shivaji Shewale, Mr. Shiv Sahebrao More, Ms. Snehal Digambar Bhamare
Country India
Abstract Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, is a vital therapeutic agent in cardiovascular diseases. This study presents a robust method for the development and validation of perindopril bulk by UV spectroscopy. The method was validated following International Conference on Harmonization (ICH) guidelines. The UV method was performed using a UV-Vis spectrophotometer. The optimized conditions involved the use of methanol as the solvent. The calibration curve was found to be linear over the concentration range of X to Y µg/ml with a correlation coefficient (r^2) of Z. The method exhibited good precision with a relative standard deviation (RSD) of less than 2%. The accuracy of the method was confirmed with a recovery study yielding results within the acceptable range. The proposed method was successfully applied for the determination of perindopril bulk in pharmaceutical formulations. The results indicate that the developed UV spectroscopic method is accurate, precise, and sensitive for the estimation of perindopril bulk. Thus, the developed method can be used for routine quality control analysis of perindopril bulk in pharmaceutical industries, ensuring its efficacy and safety.
Keywords International Conference on Harmonization, Angiotensin-Converting Enzyme (ACE), Ultra Violet Spectroscopy, Relative Standard Deviation, PERINDROPIL
Field Medical / Pharmacy
Published In Volume 7, Issue 2, March-April 2025
Published On 2025-04-20
DOI https://doi.org/10.36948/ijfmr.2025.v07i02.42256
Short DOI https://doi.org/g9f7ps
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