International Journal For Multidisciplinary Research

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Potential Role of Metformin in Central Nervous System with a Focus on Its Mechanism of Actions

Author(s) Kangkana Bora, Rajana James
Country India
Abstract Metformin is a common medication for the treatment of type 2 diabetes, which belongs to the biguanide chemical family (T2D). It's interesting that metformin's prescribed use as an anti-diabetic medicine can be expanded due to its therapeutic potential. In this regard, metformin treatment has been shown to have positive benefits on a variety of neurological diseases. In this article, we explore the metformin's positive effects as a neuroprotective agent in various neurological illnesses as well as the various suggested mechanisms of action to better understand how it works on a neurological level.
Recent research has demonstrated that metformin can pass the blood-brain barrier (BBB) and activate particular neurons and neuroglia to exert neurological effects; nevertheless, the precise way in which metformin regulates the central nervous system (CNS) is still unknown. In this review, we compiled the most recent data from preclinical studies that focused on the regulatory function of metformin in the central nervous system (CNS) and discovered that metformin can have potential neuroprotective, neurotrophic, and neurogenesis-stimulating effects. In addition, metformin also has an anti-inflammatory effect by reducing microglial activation and controlling microglial polarisation. These data suggest that the clinical use of metformin for neurological illnesses may have broad pharmacological efficacy and therapeutic insights.
Keywords Metformin, Mechanism of Action, Neurological Disorders, AMPK, Blood Brain Barrier, Neuroprotectivity.
Field Medical / Pharmacy
Published In Volume 5, Issue 4, July-August 2023
Published On 2023-07-08
Cite This Potential Role of Metformin in Central Nervous System with a Focus on Its Mechanism of Actions - Kangkana Bora, Rajana James - IJFMR Volume 5, Issue 4, July-August 2023. DOI 10.36948/ijfmr.2023.v05i04.4279
DOI https://doi.org/10.36948/ijfmr.2023.v05i04.4279
Short DOI https://doi.org/gsfxnd
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