Synthesis Of Benzimidazoles Using High Yield Thermal Method

Author(s)	Dr. Manoj Kumar, Prof. Dr. Rajesh Kumar, Mr. Aditya Kumar Maurya, Ms. Jahnvi Tripathi, Mr. Achalesh Tripathi
Country	India
Abstract	Benzimidazoles and their derivatives represent an essential class of bioactive molecules. Benzimidazole derivatives hold mechanical, biochemical, and pharmaceutical significance, and they can also serve as ligands for transition metals. Benzimidazole derivatives are known to exhibit a wide range of biological activities and can be synthesized using various solvents and ring-closing reagents. The present review focuses on the comparative synthesis of benzimidazole derivatives using both microwave and thermal methods. It has been observed that the microwave and thermal methods of synthesizing benzimidazoles and their derivatives offer several advantages, including increased yield (up to 10% to 50%) and significantly reduced reaction time (reduced by 96% to 98%) compared to conventional synthesis methods. The synthesized compounds are subjected to in vitro antibacterial and antifungal activity evaluations. Additionally, it has been observed that certain compounds exhibit remarkable anticancer activity.
Keywords	Benzimidazoles, Thermal Synthesis, High Yielding methods
Field	Chemistry
Published In	Volume 7, Issue 3, May-June 2025
Published On	2025-05-20
DOI	https://doi.org/10.36948/ijfmr.2025.v07i03.45172
Short DOI	https://doi.org/g9kt9n

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