International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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A CROSS-SECTIONAL EVALUATION OF CLINICOPATHOLOGICAL PATTERNS IN LEPROSY IN A TERTIARY HEALTH CARE FACILITY

Author(s) Dr. Shivani Pravinchandra Parmar, Dr. Shashikant Mavadiya
Country India
Abstract ABSTRACT
Mycobacterium leprae is the causative agent of leprosy, a persistent infectious granulomatous disease. 53.6% of newly reported cases worldwide each year still originate in India. The skin and peripheral nerves are the primary areas affected by leprosy. It can manifest in a variety of clinical and histological ways, contingent upon the host's cellular immunological response. Accurate leprosy diagnosis and type depend on histopathological analysis and the presence of lepra bacilli.
Aim: The objective is to evaluate the clinicopathological association between leprosy lesions.
Materials and Methods:
Twenty skin biopsy specimens from patients with a clinical diagnosis of leprosy were the subject of a three-month cross-sectional investigation at the Pathology Department of Smt.B.K.Shah Medical Institute & Research Institute, Piparia, Vadodara. Clinicohistopathological correlation was performed after skin biopsies were collected, processed, and stained with H&E stain and Fite stain to identify histopathological forms of leprosy.
Results:
The age range of 41–60 years old accounted for the majority of cases in this study (45%). The ratio of men to women was 1.5:1. The most prevalent kind was borderline tuberculoid leprosy (8 cases, 40%), which was followed by lepromatous leprosy (4 instances, 20%). All instances of lepromatous leprosy (LL), borderline lepromatous leprosy (BL), and histoid leprosy tested positive for Fite. 55% of instances showed clinico-pathological concordance.
Conclusion:
Fite staining and histopathological analysis are advised in all clinically suspected leprosy cases in order to aid in precise leprosy subtyping and diagnosis.
Keywords Keywords: Leprosy, Clinico-pathological, Fite stain, skin biopsy.
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-05-20
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.45354
Short DOI https://doi.org/g9kvdm
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E-ISSN 2582-2160
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