International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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A comprehensive study of Mapping of Hypoxia and acidosis using Advanced MRI technique.

Author(s) Mr. Bablu Malhotra, Mr. Abhi Barna, Dr. Sadhana Rai
Country India
Abstract Cancer is worldwide health problem which is faced by all over the world population. It is characterized by uncontrolled growth, division and metabolism of tissues and individual cells in order to feed the tumor and make it grow and develop resistance to treatment. Surgery, chemotherapy and radiation therapy are the conventional methods of treatment that have not proved effective treatment due to the major side effects at the site of tumor. To overcome this problem, the advanced MRI based techniques of perfusion, and metabolism imaging are used for assessing the tumor microenvironment which focuses on the partial pressure of the oxygen, which are critical for enhancing the Radiotherapy outcomes. The major cause of the Radiation resistance is caused by tumour hypoxia, and non-destructive imaging of tumour oxygenation and metabolic activity may improve treatment planning and monitoring. Since hypoxia is associated with poor treatment resistance against tumour . In this we can treat tumour hypoxia by non-destructive machine like MRI. There are various types of advanced MRI techniques which is useful for targeting the tumour site , these include DCE-MRI, BOLD-MRI, EPRI-MRI and Hyperpolarized 13C Metabolic MRI. These advanced MRI techniques examines how tumour behave during radiation therapy especially the oxygen levels and metabolism inside the tumour can be affected. The tumour with low oxygen level are difficult to kill with radiation . so the researchers explore these techniques to see how much the oxygen is in different parts of a tumour , monitor the blood flow and metabolism inside the tumour and improves the outcomes of the radiotherapy by customizing the treatment plans. EPRI-MRI (Electron Paramagnetic Resonance Imaging) is a spectrometric MRI technique which is based on NMR ( nuclear magnetic resonance). It directly maps the oxygen levels in tissue and uses a special spin probe which is injected into the body called as OX063. It creates 3D maps which shows where the tumour is low oxygenated (Hypoxic) and where the tumour is gets well oxygen supply. This paper highlights the high resolution of oxygen levels (partial pressure of oxygen) , PH gradient and inorganic phosphate (Pi ) in the tumor microenvironment . These are the efforts which are utilized to improve the outcomes of the radiotherapy and we will more focussing on increasing the oxygen level in the tumors which results in the killing of the tumor tissue.
Keywords DCE MRI, BOLD, TOLD, EPRI, HYPERPOLARIZED 13C MRI
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-06-25
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.45423
Short DOI https://doi.org/g9rnx7
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