International Journal For Multidisciplinary Research

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OPTIMIZATION AND DEVELOPMENT OF SUPRAMOLECULAR CAGE FOR AUGMENTED ORAL INSULIN DELEIVERY

Author(s) Ms. PAVITHRA PALANI, Mr. SURIYAPRASATH MURUGAN, Prof. Dr. SELVAMANI PALANISWAMY, Dr. LATHA SELVAMANI
Country India
Abstract Diabetes mellitus is a chronic metabolic disorder marked by elevated blood glucose due to either insufficient insulin production or insulin resistance. Insulin therapy, especially for Type 1 diabetes, is essential but typically involves painful subcutaneous injections, leading to poor patient compliance and discomfort. To address this, oral insulin delivery is being actively explored due to its non-invasive nature, enhanced patient adaptability, and ability to mimic natural insulin pathways by reaching the liver via the portal vein.

However, oral delivery of insulin faces major challenges due to the complex gastrointestinal (GI) environment. Insulin is a peptide hormone with high hydrophilicity, large molecular weight, and low stability, making it vulnerable to enzymatic degradation and poor intestinal absorption. These barriers significantly reduce its oral bioavailability.

Despite considerable research and ongoing clinical trials, no commercial oral insulin product has yet successfully addressed all these limitations. The lack of a viable formulation is due to the structural and physiological complexity of the GI tract.

To overcome these obstacles, several innovative formulation strategies have been developed using supramolecular cucurbit [6]uril cages to encapsulate insulin, providing a protective barrier against gastric acid degradation and enhancing its stability for effective oral delivery.
Keywords Oral insulin delivery, cucurbituril[6], tween 80, phenylalanine
Field Engineering
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-05-21
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.45534
Short DOI https://doi.org/g9mnxv
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