International Journal For Multidisciplinary Research

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Preparation and evaluation of neem loaded nanophytosomes

Author(s) Ms. Vaishnavi Jagdale, Dr. Balkrishna Tiwari, Ms. Komal Kush Jagdale, Ms. Pranali Ramkrushna Jadhav
Country India
Abstract Nanophytosomes represent a high-level advance in phytosome technology, which is needed to enhance the absorption, duration and overall efficacy of healthful components taken from plants. Phytosomes are vesicular lipid carriers which join plant-derived phytoconstituents to phospholipids to enhance their bioabsorption and effectiveness. On the basis of phytosome technology,nanophytosomes possess a nanoscale structure between 50-500 nm diameter and yet possess novel physicochemical properties and superior permeation capabilities across membranes.
Inspired by the inadequacy of traditional plant extracts like those with poor water solubility, weakly permeable through the membranes, and quickly degraded, the nanophytosomes were developed. Sealing phytochemicals in a lipophilic nanometric lipid bilayer gives rise to nanophytosomes with improved solubility, controlled release, and greater resistance to environmental exposure. As a result of these properties, nanophytosomes become an attractive tool for the delivery of various bioactive compounds including polyphenols, flavonoids, alkaloids and essential oils.
Synthesis of nanophytosomes can be done by employing multiple options – solvent evaporation, thin-film hydration and microemulsion, and each of the alternatives brings its improvement in particle size management, encapsulation efficiency, and potential of scaling up. The choice of phospholipids, surfactants, and preparation parameters has a significant influence on the size, charge and to what degree the target compounds are protected in the obtained nanophytosome.
Keywords Nanophytosomes, phytocontstituents, antimicrobial
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-06-01
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.45543
Short DOI https://doi.org/g9m2f9
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