International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

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Volume 7 Issue 3
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The Risk of Breast Cancer in Obese Individuals, the Role of Leptin - A Review

Author(s) Ms. Aseeba, Dr. Soumya
Country India
Abstract Obesity, a growing global issue, has been closely associated with an increased risk of various cancers, especially breast cancer. Elevated leptin levels, a hormone produced by fat cells, are commonly seen in obese individuals and play a pivotal role in regulating energy balance and metabolism. However, high leptin concentrations contribute to tumor growth, metastasis, and resistance to chemotherapy in breast cancer. This review delves into the intricate relationship between leptin and breast cancer, shedding light on how leptin fosters cancer progression in obese individuals by influencing inflammation, immune responses, and critical cell survival pathways. Obese breast cancer patients tend to experience poorer prognoses, greater chemotherapy resistance, and higher recurrence rates, which make the management of obesity a vital factor in breast cancer prevention and treatment. Given leptin’s involvement in cancer development and progression, further research into its role could lead to innovative therapeutic strategies aimed at targeting leptin signalling, thereby improving outcomes for obese breast cancer patients. In the long term, addressing obesity as part of cancer management could significantly reduce the global burden of breast cancer, benefiting both patient health and healthcare systems worldwide.
Keywords Breast Cancer, Tumor progression, Leptin signaling, Prognosis.
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-05-26
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.45951
Short DOI https://doi.org/g9mn3q
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E-ISSN 2582-2160
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