Optimising Dietary Interventions for MASLD: A Nutritional Perspective on Liver Heath

Sanya Lamba; Bhavana S

doi:10.36948/ijfmr.2025.v07i03.46465

Optimising Dietary Interventions for MASLD: A Nutritional Perspective on Liver Heath

Author(s)	Ms. Sanya Lamba, Dr. Bhavana S
Country	India
Abstract	Metabolic dysfunction-associated steatotic liver disease (MASLD) has become one of the leading causes of chronic liver disease globally, closely tied to obesity and insulin resistance. In the absence of approved drugs, lifestyle modification notably weight loss through diet is the cornerstone of management. This review synthesizes evidence on major dietary patterns (Mediterranean-style, low-carbohydrate high-protein, intermittent fasting) with a focus on clinical trials and RCTs done in the past 5 years. Mediterranean diets consistently reduce hepatic steatosis and improve metabolic biomarkers. In particular, a polyphenol‑enriched “green” Mediterranean diet (rich in leafy greens, walnuts, and low in red/processed meat) achieved roughly double the intrahepatic fat reduction of a standard Mediterranean regimen. Similarly, low calorie diets rich in unsaturated fats (e.g. olive oil, nuts) significantly lower liver steatosis and transaminitis. Low-carbohydrate and high-protein strategies also show significant benefits. Both a 5:2 days intermittent fasting protocol and a low-carbohydrate/high-fat diet produced significantly larger reductions in liver fat and body weight than standard care, with no difference between them. Some studies suggest that high-protein, low-carbohydrate diets may yield particularly large gains in NAFLD reversal. Overall, caloric restriction drives most of the improvement: any energy‑restricted diet markedly lowers hepatic fat, transaminases, and insulin resistance. Physical activity augments dietary effects: combining exercise with diet amplifies liver improvements. In summary, tailored dietary intervention is central in MASLD management. Diverse diets (Mediterranean, green-Mediterranean, low-carb, high-protein, intermittent fasting) can each induce clinically meaningful steatosis regression, largely via weight loss. However, consensus is lacking on the optimal diet pattern.
Keywords	Fatty liver, NAFLD, MASLD
Field	Sociology > Health
Published In	Volume 7, Issue 3, May-June 2025
Published On	2025-06-09
DOI	https://doi.org/10.36948/ijfmr.2025.v07i03.46465
Short DOI	https://doi.org/g9pzsw

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Optimising Dietary Interventions for MASLD: A Nutritional Perspective on Liver Heath

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