International Journal For Multidisciplinary Research

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COMPARITIVE ANALYSIS OF PRESCRIPTION PATTERN IN LEUKEMIA PATIENTS: AN OBSERVATIONAL STUDY

Author(s) Dr. Santosh Dayashankar Yadav, Dr. Viraj Nishad, Ms. Techi Yassa, Dr. Arpan Shrivastava
Country India
Abstract Background: Leukemia, a group of blood cancers, requires complex treatment approaches including chemotherapy, targeted therapy, and supportive care. Studying real-world prescription patterns is essential for understanding adherence to clinical guidelines, managing polypharmacy, and improving evidence-based care.
Objective: This study aimed to assess and compare the types and dosages of medications prescribed to leukemia patients, examine compliance with treatment protocols, and identify trends in rational prescribing.
Materials and Method: A six-month prospective observational study was conducted in the Oncology Department of Sri Aurobindo Hospital, Indore. The study included 70 adult inpatients diagnosed with leukemia and having complete prescription records. Data collection involved patient interviews, review of case files, and prescription analysis. Patients with incomplete records, pediatric or geriatric age, outpatients, or those with other malignancies were excluded. Chi-square tests were used to analyze the association between adherence to treatment guidelines and patient outcomes.
Result: Among the 70 patients, Acute Lymphoblastic Leukemia (ALL) was the most common (36 cases), followed by Acute Myeloid Leukemia (AML, 22), Chronic Lymphocytic Leukemia (CLL, 7), and Chronic Myeloid Leukemia (CML, 5). Methotrexate was the most commonly used antineoplastic for ALL, with Rituximab added in AML. Acivir was widely prescribed across all leukemia types. Septran-D was the most frequent antibiotic, and Voriconazole was the leading antifungal. Dexamethasone was preferred in ALL, while Hydrocortisone was commonly used in AML. Though most treatments aligned with standard protocols, statistical analysis showed no significant correlation between guideline adherence and outcomes.
Conclusion: The study emphasizes the importance of regular evaluation of prescribing trends to promote rational, patient-focused, and evidence-based leukemia care—supporting insights from literature like Kumar V et al.
Keywords Leukemia, Prescription pattern.
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-06-04
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.46912
Short DOI https://doi.org/g9m7jz
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