Advancements in Antifungal Agents: Overcoming Resistance and Exploring New Targets

Author(s)	Ms. Pooja Ramdas Hatwar, Chetan C. Turankar, Jitendra A. Kubde, RavindraL. Bakal
Country	India
Abstract	Invasive fungal infections (IFIs) continue to pose significant morbidity and mortality risks, particularly among immunocompromised individuals. Despite recent advancements in antifungal treatment, the emergence of resistance and limitations of existing agents necessitate the development of novel therapeutic strategies. This review highlights the current state of antifungal agents, including polyenes, azoles, allylamines, and echinocandins, and explores new targets for antifungal therapy. The review studies the challenges associated with existing antifungal agents, such as toxicity, resistance, and limited spectrum of activity. Emerging targets for antifungal therapy, including fungal cell wall components, plasma membrane, DNA and topoisomerases, protein synthesis, and intermediary metabolism, are also discussed. The development of novel antifungal agents with improved efficacy, safety, and spectrum of activity is crucial to address the growing threat of IFIs.
Keywords	Invasive fungal infections, Antifungal agents, new targets
Field	Medical / Pharmacy
Published In	Volume 7, Issue 4, July-August 2025
Published On	2025-07-29
DOI	https://doi.org/10.36948/ijfmr.2025.v07i04.47070
Short DOI	https://doi.org/g9vphw

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