
International Journal For Multidisciplinary Research
E-ISSN: 2582-2160
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Impact Factor: 9.24
A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal
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Volume 7 Issue 4
July-August 2025
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Advancements in Antifungal Agents: Overcoming Resistance and Exploring New Targets
Author(s) | Ms. Pooja Ramdas Hatwar, Chetan C. Turankar, Jitendra A. Kubde, RavindraL. Bakal |
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Country | India |
Abstract | Invasive fungal infections (IFIs) continue to pose significant morbidity and mortality risks, particularly among immunocompromised individuals. Despite recent advancements in antifungal treatment, the emergence of resistance and limitations of existing agents necessitate the development of novel therapeutic strategies. This review highlights the current state of antifungal agents, including polyenes, azoles, allylamines, and echinocandins, and explores new targets for antifungal therapy. The review studies the challenges associated with existing antifungal agents, such as toxicity, resistance, and limited spectrum of activity. Emerging targets for antifungal therapy, including fungal cell wall components, plasma membrane, DNA and topoisomerases, protein synthesis, and intermediary metabolism, are also discussed. The development of novel antifungal agents with improved efficacy, safety, and spectrum of activity is crucial to address the growing threat of IFIs. |
Keywords | Invasive fungal infections, Antifungal agents, new targets |
Field | Medical / Pharmacy |
Published In | Volume 7, Issue 4, July-August 2025 |
Published On | 2025-07-29 |
DOI | https://doi.org/10.36948/ijfmr.2025.v07i04.47070 |
Short DOI | https://doi.org/g9vphw |
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E-ISSN 2582-2160

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IJFMR DOI prefix is
10.36948/ijfmr
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