International Journal For Multidisciplinary Research

E-ISSN: 2582-2160     Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 7, Issue 3 (May-June 2025) Submit your research before last 3 days of June to publish your research paper in the issue of May-June.

A Review on Formulation and pharmacological activity assessment of Oral Disintegration Tablets of Antiulcer Using Super Natural Disintegrant

Author(s) Ms. Rinku Rangari, Ms. Khusbhu Rahangdale, Ms. Rudhali Lilhare
Country India
Abstract Orally disintegrating tablets (ODTs) have gained significant attention in the pharmaceutical industry due to their convenience, especially for patients with dysphagia, pediatric, and geriatric populations. The formulation of antiulcer ODTs using super natural disintegrants is a novel approach aimed at improving drug dissolution, bioavailability, and patient compliance. Omeprazole is a proton pump inhibitor (PPI) widely used in the treatment and prevention of peptic ulcers, gastroesophageal reflux disease (GERD), and other acid-related disorders. The pharmacological assessment of omeprazole for its antiulcer activity involves Omeprazole irreversibly inhibits the H⁺/K⁺ ATPase enzyme (proton pump) in the gastric parietal cells. This review provides a comprehensive analysis of the formulation techniques, selection of natural superdisintegrants, and in-vitro evaluation methods for antiulcer ODTs. Based on that review study formulation & invitro as well as invivo evaluation of OTDs will plan. The study demonstrated that the incorporation of the super natural disintegrant significantly enhanced the disintegration time and drug release profile compared to synthetic disintegrants
Keywords Oral disintegration tablets, antiulcer, super natural disintegrant, in-vitro evaluation, Omeprazole, Ulcer Index.
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-06-17
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.47424
Short DOI https://doi.org/g9qp4k

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