International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Evaluation of anticancer potentials of Oecophylla smaragdina extracts on murine ascites Dalton’s Lymphoma from Meghalaya

Author(s) Dr. Jonata Savio A Sangma, Prof. Surya Bali Prasad
Country India
Abstract Weaver ants, Oecophylla smaragdina are very fascinating ants with a unique behaviour of nest building. They use their abdominal secretion (formic acid) to avoid infection in their nest. These ants have shown utility as natural pest control agents, a source of food and in traditional medicinal practices. However, no studies have been undertaken to assess its anticancer potential. The outcome of the present study shows that the weaver ants have anticancer potential. Aqueous, ethanol and methanol extracts of adults, pupae and larvae of these ants were prepared and evaluation of anticancer properties was carried out on Dalton’s lymphoma bearing mice. It was observed that the ethanol extract of adult ants at 25 mg/kg body weight has more promising anticancer potentials. The anticancer properties were based on the findings of an increase in the life span of the tumour-bearing hosts and the development of apoptotic features in Dalton’s lymphoma cells similar to that treated with cisplatin. Histopathological effects on liver and kidney were comparatively less toxic on treatment with the weaver want extract than cisplatin. Thus, it is suggested that these ants have anticancer properties. However, the bioactive component(s) and molecular mechanisms behind its effect need to be explored.
Keywords Weaver ants, Oecophylla smaragdina, Anti-cancer activity, Dalton’s Lymphoma
Field Biology > Zoology
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-06-09
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.47644
Short DOI https://doi.org/g9pz5j
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