International Journal For Multidisciplinary Research

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Volume 7 Issue 3
May-June 2025

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SYTHESIS, CHARACTERISATION AND BIOLOGICAL INVESTIGATION OF NOVEL ISATIN SCHIFF BASE DERIVATIVES

Author(s) Mr. DHAIRYA ARUN BHEDA, Ms. DEBANGANA INDRANIL BANERJEE, Ms. ANSHU BABURAO BOMBARDAE, Ms. CHINMAI VIVEKANAND JAITAPKAR, Ms. MUGDHA MAHESH BHOSALE, Mr. AVINASH RANGARAJU
Country India
Abstract This research explores the synthesis, characterization, and biological evaluation of novel Schiff base derivatives of Isatin, a bioactive heterocyclic compound. Five derivatives (A1–A5) were synthesized via condensation reactions involving Isatin, p-phenylenediamine, and various aromatic aldehydes. Characterization was achieved through thin layer chromatography, melting point analysis, Fourier Transfer-Infrared Spectroscopy, 1H-Nuclear Magnetic Resonance and 13C-Nuclear Magnetic Resonance. Antibacterial activity was assessed using the agar diffusion method and minimum inhibitory concentration were determined using broth microdilution method against Gram-positive and Gram-negative strains. The research emphasizes that the synthesized compounds exhibited statistically significant and biologically relevant antibacterial activities. These findings highlight the importance of specific substitution patterns on the Isatin scaffold in enhancing antimicrobial efficacy. The work lays a foundation for further pharmacokinetic and structure-activity relationship studies and supports the potential of these Schiff base derivatives as promising candidates in the development of multifunctional therapeutic agents.
Keywords Isatin, Schiff base, Anti-bacterial Activity, Minimum Inhibitory Concentration
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-06-14
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.48024
Short DOI https://doi.org/g9qqdc
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