International Journal For Multidisciplinary Research

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Formulation and In-Vitro Evaluation Studies on Oral Disintegration Tablets of Antiulcer Using Super Natural Disintegrants

Author(s) Ms. Arti Bhagat, Ms. Neha Dubey, Mr. Anees Ahmed, Mr. Satyam Shrivastava
Country India
Abstract The demand for orally disintegrating tablets (ODT) has been growing the last decade especially for elderly and children who have swallowing difficulties The present study focuses on the formulation and evaluation of orally disintegrating tablets (ODTs) for the treatment of ulcers, utilizing a super natural disintegrant.. Oral bioavailability of Omeprazole is 40% after a single dose and increases to 65% with repeated dosing and having a half life of 0.5 to 1.5 hrs. The study involves the formulation of ODTs containing an antiulcer agent, the selection of an optimal super natural disintegrant, and the in-vitro& in-vivo evaluation of the tablets. The formulated tablets were subjected to pre-compression and post-compression evaluations, including disintegration time, dissolution studies, hardness, friability, and drug content uniformity, in vitro drug release studies. Oral disintegrating tablets (ODT) of Omeprazole using natural superdisintegrants, synthetic superdisintegrants and coprocessed excipients were prepared by direct compression method. The superdisintegrants used in the study were polyplasdone and fenugreek seed powder in varying concentrations. The optimized formulation showed the minimum disintegration time of 15secs and release maximum amount of drug in 30 min. Short term stability studies indicated no significant changes in hardness, friability, in vitro disintegration time, drug content and in vitro drug release. The results demonstrated that the incorporation of the super natural disintegrant significantly enhanced the disintegration time and drug release profile compared to synthetic disintegrants.
Keywords Oral disintegration tablets, antiulcer, super natural disintegrant, in-vitro evaluation, formulation.
Field Medical / Pharmacy
Published In Volume 7, Issue 4, July-August 2025
Published On 2025-07-13
DOI https://doi.org/10.36948/ijfmr.2025.v07i04.48197
Short DOI https://doi.org/g9s886
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