International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 7 Issue 3
May-June 2025

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“Identifying Predictive Biomarkers of Oxidative Stress in COVID-19: The Role of Vitamin D, Calcium, and Vitamin E”

Author(s) Dr. PRIYAM CHAUHAN
Country India
Abstract COVID-19 is a viral infection caused by the SARS-CoV-2 virus, amplifying global health complexities. An important part of the knowledge of the disease and ways to prevent it is the search for biomarkers for the assessment of the occurrence of oxidative stress in patients with COVID-19. Thus, the current review is concerned with the functionality of Vitamin D, Calcium, and Vitamin E as biomarkers to predict the level of oxidant strain in COVID patients. Vitamin D is proven to possess immunomodulatory and antioxidant functions, regulatory effects on the antioxidant enzyme, and cytokine inhibitory effects. Analyzing clinical trials suggests the association of low Vitamin D levels with higher coronavirus threat, hence the possibility of the vitamin as a biomarker of coronavirus advancement. Calcium is a biologically active ion that participates in many processes within a cell and contributes to oxidative stress regulation; in COVID-19 patients, their calcium balance becomes disrupted, with hypocalcemia being particularly ominous. Lastly, Vitamin E, which is a lipid-soluble, antioxidants strengthens cell membranes by eliminating free radicals and further regulates the immune system. Initial case-control research findings suggest that sufficient Vitamin E can enhance the clinical outcomes of COVID-19 patients because of the decrease in oxidative stress. This review concerns the current state of knowledge about these micronutrients, including their biochemistry and clinical data, and their potential applications in the treatment of COVID-19.
Keywords COVID-19, oxidative stress, Vitamin D, Calcium, Vitamin E
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-06-15
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.48236
Short DOI https://doi.org/g9qqnh
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