International Journal For Multidisciplinary Research

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Formulation and Evaluation of Immediate Release Dasatinib Film Coated Tablet

Author(s) Ms. chanukya senapathi, Ms. SwarupaRani vemuru, Ms. Dharani Lakshmi Sadam, Mr. Vijay Boddu, Mr. Venu Gopal Chennupalli
Country India
Abstract ABSTRACT:
This study focuses on the Formulation and Evaluation of Immediate Release Dasatinib Film Coated Tablet. Oral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage forms. Various formulations were prepared by direct compression technique using super disintegrants (cross carmellose sodium, sodium starch glycolate etc.) The main objective is to achieve immediate drug release profile for the developed formulation. Optimized formulation was selected and its in-vitro release profile should be comparable with the reference product (Sprycel). The Stability studies were performed on the optimized formulation. Formulation of tablets by direct compression method. Evaluation of formulated tablets by performing various tests. Dasatinib, Microcrystalline cellulose, Chemicals are used. The formulation and evaluation of immediate release Dasatinib film coated tablets for the treatment of Lymphoblast Phase chronic myeloid leukemia. this preformulating studies performed for the drug and excipients as per the standard procedure. Immediate release drug delivery is a conventional type of drug delivery. The optimized formulation was subjected to stability studies and it was found to be stable.
Keywords Key word: Dasatinib, cross Carmel lose sodium, sodium starch glycolate , crospovidone.
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-06-28
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.49054
Short DOI https://doi.org/g9rsm2
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