International Journal For Multidisciplinary Research

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Semmes Weinstein Monofilament Test vs Vibration Perception Tests for Detection of Diabetic Peripheral Neuropathy: A Systematic Review and Meta-analysis

Author(s) Dr. Glaisa Angeles Claveria
Country Philippines
Abstract Diabetic peripheral neuropathy (DPN) is a serious diabetic complication with high morbidity. This systematic review and meta-analysis sought to compare the diagnostic accuracy of the Semmes-Weinstein Monofilament Test (SWMT) and Vibration Perception Tests (VPT) in detecting DPN.Nine studies published between 2020 and 2024 were included, with heterogeneous populations and different methodologies. Effect sizes presented in the form of correlation coefficients (r), standardized mean differences (SMD), or diagnostic odds ratios (DOR) were converted to a standard metric (Pearson's r) for amalgamation analysis. Random-effects meta-analytic models were used to aggregate diagnostic accuracy estimates, and heterogeneity between studies was tested using Q-statistics, I², and τ². The risk of bias was determined using the QUADAS-2 tool. Pooled Fisher's z at 1.03 (95% CI: 0.11–1.94) is equivalent to a mean correlation coefficient of r = 0.77 (95% CI: 0.11–0.96), reflecting excellent diagnostic performance in both tests. Significant heterogeneity was evident (Q = 71.14, I² = 95.78%, τ² = 0.84). Subgroup analysis indicated that VPT has slightly higher sensitivity, while SWMT continues to be a useful screening test in the primary care setting, given its low cost and ease. Both VPT and SWMT are reliable for the detection of DPN. VPT potentially provides slightly better diagnostic accuracy, but SWMT is invaluable as a frontline screening tool, particularly in resource-poor settings. Both diagnostic methods together are recommended for complete assessment.
Keywords Diabetic peripheral neuropathy, Semmes Weinstein Monofilament Test, Vibration perception test, Systematic Review, Meta-Analysis, Diagnostic Accuracy
Field Medical / Pharmacy
Published In Volume 7, Issue 3, May-June 2025
Published On 2025-06-25
DOI https://doi.org/10.36948/ijfmr.2025.v07i03.49184
Short DOI https://doi.org/g9rskt
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