A Review on Solid Dispersion Techniques: A Exclusive Approach for Enhancing Drug Solubility and Bioavailability

Author(s)	Ms. AJANTA JANARDAN TOTRE, Dr. GITA CHAURASIA
Country	India
Abstract	Insufficient aqueous solubility presents a major obstacle in drug development, resulting in diminished bioavailability and potential therapeutic failure. Solid dispersion techniques represent an efficient approach to improve the solubility and dissolution rates of drugs with poor water solubility. Different carriers like surfactants or co-solvents, polymers etc. are used to enhance the solubilization of poorly water-soluble drugs using different approaches. This article includes various methods of solid dispersion, such as fusion, solvent evaporation, hot-melt extrusion, and spray drying, while emphasizing their mechanism, advantages, disadvantages, challenges, pharmaceutical applications, marketed formulations and future perspectives in global market. Additionally, it discusses the influence of carrier selection, stability issues, and prospective research avenues.
Keywords	Solid dispersion, Solubility enhancement, Drug delivery, Bioavailability enhancement, pharmaceutical carriers.
Field	Medical / Pharmacy
Published In	Volume 7, Issue 3, May-June 2025
Published On	2025-06-28

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