Phytochemical Profiling of MARMAGULIKA LEPAM Using GC-MS Analysis: Identification of Volatile and Bioactive Compounds

Sreedevi A P; Reeshma CR; Anju Antony; Sibi Narayana

doi:10.36948/ijfmr.2025.v07i04.50025

Phytochemical Profiling of MARMAGULIKA LEPAM Using GC-MS Analysis: Identification of Volatile and Bioactive Compounds

Author(s)	Dr. Sreedevi A P, Reeshma CR, Anju Antony, Sibi Narayana
Country	India
Abstract	Introduction: Marmagulika Lepam (MG Lepam), a polyherbal Ayurvedic formulation from Sahasrayogam, is used topically for its anti-inflammatory and analgesic properties in treating dermatological and musculoskeletal disorders. Unlike synthetic drugs, MG Lepam offers a natural alternative with minimal side effects, leveraging a diverse mix of herbal ingredients. Materials and Methods: Raw materials were sourced and MG Lepam was prepared per classical Ayurvedic protocols, triturating powdered herbs with decoctions to form a homogeneous paste. Organoleptic, physicochemical, phytochemical, Heavy metal Analysis and GC-MS analyses were conducted to assess the formulation’s properties and safety.Results and Discussion: MG Lepam exhibited a dark brown color, characteristic odor, and smooth consistency. Its pH (4.98) aligns with skin compatibility, with 53.1% moisture and 5981 cP viscosity ensuring stability and spreadability. Phytochemical analysis confirmed carbohydrates, sugars, proteins, glycosides, phenols, saponins, and quinones, supporting its therapeutic effects. HMT showed negligible heavy metal levels. GC-MS identified bioactive compounds like palmitic (12.279%), oleic (16.454%), and linoleic (12.542%) acid methyl esters, contributing anti-inflammatory, antioxidant, and antimicrobial properties, with cyclohexanol (25.543%) enhancing transdermal absorption.Conclusion: MG Lepam is a safe, effective topical Ayurvedic formulation, validated by comprehensive analyses. Its skin-compatible properties and bioactive compounds support its use for pain and inflammation management, offering a natural alternative to synthetic analgesics and a model for standardizing Ayurvedic formulations for global healthcare integration.
Keywords	Marmagulika Lepam, Anti-inflammatory, GC-MS Analysis, Phytochemicals, Heavy Metal Toxicity, Topical Application
Published In	Volume 7, Issue 4, July-August 2025
Published On	2025-07-30
DOI	https://doi.org/10.36948/ijfmr.2025.v07i04.50025
Short DOI	https://doi.org/g9vphm

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Phytochemical Profiling of MARMAGULIKA LEPAM Using GC-MS Analysis: Identification of Volatile and Bioactive Compounds

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