International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 7 Issue 4
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Antifungal efficacy of different herbal extracts as irrigants against Candida albicans – An Invitro Study

Author(s) Prof. Dr. KRISHNA PRASADA L, Dr. GUNJAN CHAWLA
Country India
Abstract Objectives: To disinfect the root canal space, biomechanical preparation and irrigation with antimicrobial treatments are required. The nature of endodontic infections is polymicrobial. The most frequent fungus isolated from unsuccessful endodontic cases is Candida albicans. This in-vitro study focused on the antifungal activity of Psidium guajava leaf extract and Allium sativum extract on Candida albicans biofilm developed in root canals of teeth.
Materials and Methods: 30 extracted human mandibular premolars will be biomechanically prepared, vertically sectioned, and placed in tissue culture wells exposing the root canal surface to C. albicans grown on Sabouraud Dextrose Agar to form a biofilm. At the end of 2 days, 3 groups of 10 extracted teeth will be treated with test solutions (Psidium guajava leaf extract, Allium sativum extract) and control (saline) for 10 min and evaluated for Candida growth and number of colonies forming units. The data will be collected and analyzed using the ANOVA test and independent student t-test.
Results: Microbial count was maximum in the saline group and minimum in the garlic extract group. Guava leaf extract group also showed a higher antifungal efficacy as compared with saline group.
Clinical relevance – This study helps in evaluating different irrigants for the removal/reduction of the most commonly found fungi in root canals i.e. candida albicans
Keywords Candida albicans, Psidium guajava leaf extract, Allium sativum extract
Field Medical / Pharmacy
Published In Volume 7, Issue 4, July-August 2025
Published On 2025-07-30
DOI https://doi.org/10.36948/ijfmr.2025.v07i04.50421
Short DOI https://doi.org/g9vpkw
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