Consequences and Therapeutics of Reactive Oxygen Species (ROS) in Depression- A Systematic Review

Author(s)	Ms. VANITA JAMBA, Dr. BIJAY PATTNAIK, Dr. SANDESH CHIBBER
Country	India
Abstract	Depression, a prevalent psychiatric disorder, affects 15% of the population and up to one-sixth of the general population. Research suggests a relationship between stress and depressive episodes, with most severe events leading to depression within the first month. The monoamine hypothesis suggests depression is caused by decreased functioning in noradrenaline and/or serotonin, but this symmetry is incorrect due to differences in neural bases. Reactive oxygen species (ROS) are crucial in human physiological and pathological processes, causing irreversible functional changes or destruction. Treatments for ROS have been effective in treating conditions like Chronic Respiratory Syndrome, depression, and oxidative stress. Research shows that ROS can cause alterations in cellular metabolic activities and can be reduced in various ways. Further research is needed to understand ROS and its potential as a biomarker and treatment agent.
Keywords	Reactive Oxygen Species (ROS), Depression, Antidepressants, NADPH oxidase, Major Depressive Disorder (MDD), antioxidants, Oxidative stress
Field	Biology > Genetics / Molecular
Published In	Volume 7, Issue 4, July-August 2025
Published On	2025-07-15
DOI	https://doi.org/10.36948/ijfmr.2025.v07i04.51121
Short DOI	https://doi.org/g9s9sx

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