International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

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Volume 7 Issue 4
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Need of Customized Parenteral therapies for pediatrics and geriatric

Author(s) Mr. Vaibhav Mahadeo Shriram, Ms. Rutuja Dnyandev Pawar
Country India
Abstract Making safe and effective parenteral therapies for children and older adults is important due to their body responses. These two age groups have distinct physiological conditions, from immature organs in infants to declining kidney and liver function in the elderly—that mainly affect how drugs behave in the body. As a result, off-the-shelf formulations often fall short, either risking toxicity or failing to deliver the intended therapeutic effect. This growing field has pushed researchers and clinicians to design more customized solutions for these various populations. In pediatric care, rapid growth, varying body composition, and an evolving immune system make standard drug dosing unpredictable. Meanwhile, older adults commonly face multiple chronic conditions, take more medications, and process drugs more slowly—all factors that demand precise and cautious dosing strategies. Both groups benefit from formulations that are not just age-appropriate but also easier to administer, better tolerated, and more adaptable to their clinical realities. This review highlights recent innovations in parenteral drug delivery customized to the needs of pediatric and geriatric patients. It examines formulation techniques such as controlled release systems, nano-sized carriers, solvent-free preparations, and the appropriate selection of excipients that reduce adverse reactions. Apart from formulation, the article also looks at the practical side of care, including dose customization, drug compatibility, sterility standards, and the critical role of monitoring therapeutic levels. The review also describes regulatory perspectives, age-specific trial designs, and how real-world clinical data is reforming the development of injectable drugs. Advances in biotechnology and personalized medicine are creating exciting possibilities for therapies that truly fit the individual—not just their diagnosis, but their age, metabolism, and treatment setting. In core, this article emphasizes the importance of moving away from one-size-fits-all approaches. With smarter formulations and a deeper understanding of patient-specific needs with their physiological conditions. We can significantly improve outcomes and safety for the youngest and oldest members of our healthcare system.
Keywords Distinct Physiological Needs in Pediatrics and Geriatrics Challenges in Accurate and Safe Dosing Lack of Age-Appropriate Parenteral Formulations Higher Risk of Adverse Drug Events Emerging Role of Technology in Personalized Therapies Importance of Therapeutic Drug Monitoring (TDM) Customized Parenteral Nutrition in Special Populations Case-Based Insights in Clinical Practice Need for Multidisciplinary Team Collaboration Innovative Future Directions in Parenteral Drug Delivery
Field Medical / Pharmacy
Published In Volume 7, Issue 4, July-August 2025
Published On 2025-07-25
DOI https://doi.org/10.36948/ijfmr.2025.v07i04.51871
Short DOI https://doi.org/g9vpjz
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