International Journal For Multidisciplinary Research

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Comparative Analysis of Time to Achieve Target Blood Parameters in Patients with Venous Thromboembolism Receiving Ufh and Lmwh

Author(s) Ms. Jincy Elsam John, Ms. Namitha Rachel Biji, Ms. Riona Mathew, Dr. Elessy Abraham
Country India
Abstract Venous Thromboembolism (VTE) is a serious and potentially life-threatening condition characterized by the formation of blood clots usually occuring in the deep veins of the legs causing deep vein thrombosis (DVT) and sometimes the clot may travel to the lungs and cause a pulmonary embolism (PE). It develops as a result of endothelial injury, hypercoagulable state or stagnant blood flow (1). The factors that contribute to VTE include prolonged immobility due to any major surgeries and in conditions like cancer, pregnancy, or inherited clotting disorders (2). The symptoms of DVT include leg pain, swelling, warmth, and redness, while PE commonly presents with sudden onset of chest pain, shortness of breath, tachycardia, and sometimes hemoptysis. The diagnosis of VTE includes a combination of clinical assessment, D-dimer values, Doppler tests, CT pulmonary angiography (3). Treatment include drugs like Unfractionated Heparin (UFH), Low Molecular Weight Heparin (LMWH), oral anticoagulants, thrombolytics or procedures like thrombectomy (4). This study aims to estimate the time taken for blood parameters like D-dimer, platelet APTT, INR and prothrombin time which are usually abnormal in VTE conditions to achieve desirable levels by using UFH and LMWH (5). In our study there were 96 VTE patients among which 36 patients were treated with UFH and 63 were treated with LMWH. The results obtained suggested that both heparins were equally effective in normalising the abnormal blood parameters.
Keywords Venous Thromboembolism (VTE), Deep Vein thrombosis (DVT), pulmonary embolism (PE), Unfractionated Heparin (UFH), Low Molecular Weight Heparin (LMWH)
Field Medical / Pharmacy
Published In Volume 7, Issue 4, July-August 2025
Published On 2025-07-25
DOI https://doi.org/10.36948/ijfmr.2025.v07i04.52023
Short DOI https://doi.org/g9vpwx
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