International Journal For Multidisciplinary Research

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Trained Immunity and Epigenetic Reprogramming in Microglia: A Novel Axis in Alzheimer’s Disease Neuroinflammation

Author(s) Ms. KEERTHI THODIYIL
Country India
Abstract Innate immune cells known as microglia perform a key role in the neuroinflammation that leads to Alzheimer's disease (AD). Studies reported that microglia have recently been demonstrated trained immunity, a long-term variation in immune response triggered by past stimuli and regulated by metabolic process and epigenetic reprogramming. These alterations affect amyloid clearance, neuronal destructions, and the progress of the disease by either stimulating immunological tolerance or elevated inflammatory responses. Hence, in this scenario, the mechanisms of trained immunity and epigenetic programming in microglia are thoroughly analysed in this report, with an emphasis on chromatin remodelling, metabolic variations, and histone alterations. Grasping these mechanisms reveals innovative perspectives on the ongoing neuroinflammation in AD and recognizes potential treatment strategies to alter microglial activity and avert neurodegeneration.
Keywords Innate immune cells known as microglia perform a key role in the neuroinflammation that leads to Alzheimer's disease (AD). Studies reported that microglia have recently been demonstrated trained immunity, a long-term variation in immune response triggered by past stimuli and regulated by metabolic process and epigenetic reprogramming. These alterations affect amyloid clearance, neuronal destructions, and the progress of the disease by either stimulating immunological tolerance or elevated inflammatory responses. Hence, in this scenario, the mechanisms of trained immunity and epigenetic programming in microglia are thoroughly analysed in this report, with an emphasis on chromatin remodelling, metabolic variations, and histone alterations. Grasping these mechanisms reveals innovative perspectives on the ongoing neuroinflammation in AD and recognizes potential treatment strategies to alter microglial activity and avert neurodegeneration.
Field Biology > Genetics / Molecular
Published In Volume 7, Issue 4, July-August 2025
Published On 2025-07-30
DOI https://doi.org/10.36948/ijfmr.2025.v07i04.52474
Short DOI https://doi.org/g9vpmz
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