Biochemical and Pathomorphological evaluation of Efficacy of Swertia chirayita Extract in Streptozotocin Induced Diabetic Wister Rats

Author(s)	Manjunatha K P K P, Sathyanarayana, M. L M L, Shesha rao Rao
Country	India
Abstract	The alcoholic extract of Swertia chirayita extract was tested for its biochemical and pathomorphological effects in streptozotocin induced diabetes in rats. Streptozotocin produced diabetes effectively in all the animals at 45 mg/kg b.w. intraperitonially. The diabetic animals showed significant increase in serum levels of glucose, cholesterol, triglycerides, ALT and AST. Swertia chirayita treated rats at the dose of 500 mg/kg b.w showed significant reduction in the serum levels of glucose, cholesterol, triglycerides, ALT and AST with significant improvement in diabetic animals from day 3 post treatments till the end of the study. Swertia chirayita also improved the damage caused by streptozotocin morphologically in pancreas by promoting the regeneration of beta cells of islets of Langerhans.
Keywords	Diabetes, Swertia chirayita, Streptozotocin.
Field	Chemistry > Pharmacy
Published In	Volume 1, Issue 2, September-October 2019
Published On	2019-09-09

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