International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 7 Issue 4
July-August 2025

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Helminthic Therapy as Modern Immunotherapy

Author(s) Dr. Nikhitha Reddy Musku
Country India
Abstract Helminthic therapy, the deliberate introduction of benign parasitic worms, has emerged as a novel approach to manage autoimmune and allergic diseases. This concept draws on the hygiene hypothesis, which suggests that reduced exposure to parasites and microbes in modern, sanitized societies contributes to rising immune dysregulation. Helminths have co-evolved with humans, acting as natural immunoregulators to maintain balance. Experimental and clinical studies have demonstrated promising outcomes in conditions such as crohn’s disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis, and allergic disorders. Specific species, including Trichuris suis ova and Necator americanus, are under investigation due to their relatively safe profiles and immunomodulatory effects. Additionally, helminth-derived molecules and related biotherapies, such as medicinal leech therapy, offer complementary treatment options for immune modulation. However, challenges remain regarding safety, standardization, ethical concerns, and patient acceptance. This review highlights the scientific basis, mechanisms, current evidence, and limitations of helminthic therapy, emphasizing its potential as an adjunct in the management of immune-mediated disorders.
Keywords Hygiene hypothesis, Immune modulation, Autoimmune diseases, Microbiome, Parasite
Field Biology > Zoology
Published In Volume 7, Issue 4, July-August 2025
Published On 2025-07-31
DOI https://doi.org/10.36948/ijfmr.2025.v07i04.52557
Short DOI https://doi.org/g9vpqc
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E-ISSN 2582-2160
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