
International Journal For Multidisciplinary Research
E-ISSN: 2582-2160
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Impact Factor: 9.24
A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal
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Volume 7 Issue 4
July-August 2025
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Helminthic Therapy as Modern Immunotherapy
Author(s) | Dr. Nikhitha Reddy Musku |
---|---|
Country | India |
Abstract | Helminthic therapy, the deliberate introduction of benign parasitic worms, has emerged as a novel approach to manage autoimmune and allergic diseases. This concept draws on the hygiene hypothesis, which suggests that reduced exposure to parasites and microbes in modern, sanitized societies contributes to rising immune dysregulation. Helminths have co-evolved with humans, acting as natural immunoregulators to maintain balance. Experimental and clinical studies have demonstrated promising outcomes in conditions such as crohn’s disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis, and allergic disorders. Specific species, including Trichuris suis ova and Necator americanus, are under investigation due to their relatively safe profiles and immunomodulatory effects. Additionally, helminth-derived molecules and related biotherapies, such as medicinal leech therapy, offer complementary treatment options for immune modulation. However, challenges remain regarding safety, standardization, ethical concerns, and patient acceptance. This review highlights the scientific basis, mechanisms, current evidence, and limitations of helminthic therapy, emphasizing its potential as an adjunct in the management of immune-mediated disorders. |
Keywords | Hygiene hypothesis, Immune modulation, Autoimmune diseases, Microbiome, Parasite |
Field | Biology > Zoology |
Published In | Volume 7, Issue 4, July-August 2025 |
Published On | 2025-07-31 |
DOI | https://doi.org/10.36948/ijfmr.2025.v07i04.52557 |
Short DOI | https://doi.org/g9vpqc |
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E-ISSN 2582-2160

CrossRef DOI is assigned to each research paper published in our journal.
IJFMR DOI prefix is
10.36948/ijfmr
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