International Journal For Multidisciplinary Research

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Evaluation of median Time For complete discontinuation of UF Heparin and LMWH in venous Thromboembolism patients at tertiary care hosptals

Author(s) Dr. Riona Mathew, Dr. Jincy Elsam John, Dr. Namitha Rachael Biji, Prof. Dr. Elessy Abraham
Country India
Abstract Venous Thromboembolism (VTE) presents a significant clinical challenge in tertiary care, requiring prompt and effective anticoagulation therapy. Unfractionated Heparin (UFH) and Low Molecular Weight Heparin (LMWH) are common therapeutic options, but their relative efficacy in this context remains debated. We conducted a retrospective study of patients diagnosed with VTE in our tertiary care facility over a six- month period. Patients were stratified into two groups based on their initial anticoagulation therapy: UFH or LMWH. The main outcome assessed was median time taken for complete stoppage of both the anticoagulants. Among the included patients (n=96), 53 were females and 43 were males. Out of which 36.46% received UFH and 63.54% received LMWH as initial therapy.
The median time taken for complete stoppage of overall treatment with UF heparin was 26 weeks (6.5 months) and LMWH was 22 weeks (5.5 months). The study reinforces the finding that UFH treatment might require a longer duration (almost a month) compared to LMWH for complete stoppage. Thus, considering certain factors like cost, treatment duration and de-escalation protocols, UFH emerges to be a more advisable option in clinical practice especially in low- resource setting where cost is the main concern
Keywords Key-words- Venous Thromboembolism, Unfractionated Heparin, low molecular weight heparin
Field Medical / Pharmacy
Published In Volume 7, Issue 4, July-August 2025
Published On 2025-08-01
DOI https://doi.org/10.36948/ijfmr.2025.v07i04.52633
Short DOI https://doi.org/g9vzkz
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