International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Bilateral Orbital Plasmacytoma in Multiple Myeloma: a Case Report and Literature Review

Author(s) Dr. Denise Edith Tatiana Ngbwa, Dr. Falone Amoussou, Dr. Ndèye Marieme Diagne, Dr. Carine Wandaogo, Dr. Moustapha Etape, Dr. Jean Baptiste Kacou, Prof. Karima Nouni, Prof. Amine Lachgar, Prof. Hanan El Kacemi, Prof. Tayeb Kebdani, Prof. Khalid Hassouni
Country Morocco
Abstract Orbital plasmacytoma, a rare but biologically aggressive extramedullary neoplasm associated with multiple myeloma (MM), represents a major diagnostic and therapeutic challenge. This publication presents a representative clinical case of a 55-year-old female patient diagnosed with IgG Lambda multiple myeloma and bilateral orbital plasmacytoma refractory to chemotherapeutic agents. The in-depth analysis of clinical data and the subsequent discussion highlight the characteristic clinical manifestations of exophthalmos, fulminant tumor progression, and the imperative need for a multimodal therapeutic strategy, particularly local palliative irradiation (20 Gy delivered in 5 fractions). This case illustrates the efficacy of this approach in achieving local tumor control and preserving the ocular globe, with a notable reversal of pre-existing blindness. This underscores the imperative for diligent and multidisciplinary therapeutic intervention to maximize functional benefits and minimize the deleterious repercussions of this complication, particularly in immunocompromised subjects.
Keywords Multiple Myeloma, Orbital Plasmacytoma, Exophthalmos, Palliative Radiotherapy, Bilateral, Case Report
Field Medical / Pharmacy
Published In Volume 7, Issue 4, July-August 2025
Published On 2025-08-28
DOI https://doi.org/10.36948/ijfmr.2025.v07i04.53701
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E-ISSN 2582-2160
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