International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Ultraviolet Spectrophotometric Estimation of Nebivolol Hydrochloride In Bulk And Formulation

Author(s) Ms. Shweta Sanjaykumar Pal, Dr. Gita Chaurasia, Dr. Swati Deshmukh
Country India
Abstract The present work focussed on developing the Ultraviolet spectroscopic (UV) analytical method for analysis of Nebibolol Hydrochloride (NH) in bulk and formulation, used in the treatment of hypertension, heart attack, migraine and stroke. It is a beta blocker that works by slowing down the heart rate and makes heart more efficient pumping of blood within the body. The precise, convenient, simple, sensible and reproducible UV methods were developed, in solvents A, B & C having analytical grade pure Methanol, Methanol:Phosphate buffer pH 6.8 (PB) in ratio of 1:9 and Ethanol: Propylene glycol (1:9) solution (EP), respectively. Each were scanned in range of 200-400 nm at concentration of 10µg/ml. The linearity with high sensitivity was obtained in the range from 10-50μg/ml in solvents A, B and C, via Double beam UV Visible Spectrophotometer. The absorption maxima were showed at 281.0 nm; 284.0 nm and 282.0 nm, respectively. ICH Q2B guidelines were followed to validate the method using parameters (Range, Linearity, Robustness, Precision, Ruggedness, Accuracy, Limit of detection (LOD) and Limit of quantification (LOQ), by using predefined calibration standards for the developed methods. Marketed formulation Toricard-5 tablets were used for method validation in each solvent A, B & C, in which the percentage average drug recovery was found to be 99.73; 99.84 & 98.82, respectively (n=6). In conclusion, the proposed method was successfully developed in chosen solvents and validated for the determination of NH in bulk and formulations.
Keywords Nebibolol Hydrochloride, Estimation of Nebibolol Hydrochloride, UV methods, Nebibolol Hydrochloride analysis, Anti- hypertensive drug, Treatment of migraine
Field Medical / Pharmacy
Published In Volume 7, Issue 4, July-August 2025
Published On 2025-08-27
DOI https://doi.org/10.36948/ijfmr.2025.v07i04.54473
Short DOI https://doi.org/g9z27f
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