International Journal For Multidisciplinary Research

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RP-HPLC Method Development and Validation for Estimation of Bisoprolol and Hydrochlorothiazide

Author(s) Bhargavi Pacchipala, Alekhya Somepalli, Nanda Gopala Krishna Gona, Sony Priyanka Arava, T.Lakshmi Durga
Country India
Abstract The present study was to develop a rapid and sensitive method for the analysis of Bisoprolol and Hydrochlorothiazide by different analytical methods such as UV spectrophotometry and RP-HPLC in pharmaceutical dosage forms by using the most commonly employed C-18 column with UV-detection and validate it as per ICH guidelines. The retention time for Bisoprolol and Hydrochlorothiazide was found to be 2.1 min and 4.01 min respectively. A Resolution of greater than 2 was observed. The low % RSD values (≤ 2) indicated that the method was precise and accurate. The mean recoveries were found in the range of 99.1 – 99.9% w/w. Our approach was specific with good accuracy and precision when evaluating the commercial formulations without the interference of excipients and other additives. This method can be used to calculate the amounts of Bisoprolol and Hydrochlorothiazide in both single and mixed pharmaceutical formulations, as well as bulk samples.
Keywords RP-HPLC, UV Spectrophotometry, Bisoprolol, Hydrochlorothiazide, Column.
Field Chemistry > Pharmacy
Published In Volume 5, Issue 4, July-August 2023
Published On 2023-08-20
Cite This RP-HPLC Method Development and Validation for Estimation of Bisoprolol and Hydrochlorothiazide - Bhargavi Pacchipala, Alekhya Somepalli, Nanda Gopala Krishna Gona, Sony Priyanka Arava, T.Lakshmi Durga - IJFMR Volume 5, Issue 4, July-August 2023. DOI 10.36948/ijfmr.2023.v05i04.5519
DOI https://doi.org/10.36948/ijfmr.2023.v05i04.5519
Short DOI https://doi.org/gsmnmj
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