International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 8, Issue 2 (March-April 2026) Submit your research before last 3 days of April to publish your research paper in the issue of March-April.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 8 Issue 2
March-April 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

The Cognitive Footprint of Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) in Chimeric Antigen Receptor T-Cell Therapy (CAR-T): A Systematic Review

Author(s) Ms. Purvi Jain, Ms. Amreen Kaur, Ms. Anjali Gupta
Country India
Abstract Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) presents a significant side-effect of CAR-T cell therapy, with cognitive dysfunction emerging as a core manifestation that can impact patient quality of life and their functional outcomes.To systematically review current evidence on the clinical impact, underlying mechanisms, assessment methodologies, and management strategies of ICANS-related cognitive dysfunction in CAR-T recipients.A systematic literature search was conducted across PubMed, EMBASE, Google Scholar and Web of Science databases following PRISMA guidelines. Studies reported ICANS affects 26.9% of CAR-T recipients overall, with cognitive dysfunction representing the most prevalent manifestation. Deficits in attention, memory, executive function, and language processing were consistently reported, with varying degrees of persistence ranging from days to months post-treatment.ICANS-related cognitive dysfunction represents a significant clinical concern requiring standardized assessment protocols and targeted interventions. Further research is needed to establish predictive biomarkers and effective management strategies.
Keywords ICANS, Cognition, CAR-T Therapy, Oncology, Psych-oncology
Field Medical / Pharmacy
Published In Volume 7, Issue 5, September-October 2025
Published On 2025-10-26
DOI https://doi.org/10.36948/ijfmr.2025.v07i05.56013
View / Download PDF File

Share this



E-ISSN 2582-2160
CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJFMR DOI prefix is
10.36948/ijfmr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 8 Isu 2Cover Page Vol 8 Isu 1Cover Page Vol 7 Isu 6

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJFMR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9687-828-838 editor@ijfmr.com
Powered by Sky Research Publication and Journals