Antimicrobial Photodynamic Therapy (aPDT) in Resistant Endodontic Infections: A Promising Adjunct in Root Canal Disinfection

Author(s)	Dr. R Sumukh Bharadwaj
Country	India
Abstract	Antimicrobial resistance within root canal infections presents a significant challenge to conventional endodontic disinfection strategies. The persistence of microorganisms such as Enterococcus faecalis and Candida albicans in complex root canal anatomies often leads to treatment failure. Antimicrobial photodynamic therapy (aPDT) has emerged as a promising adjunct to conventional irrigation protocols, combining photosensitizers with specific wavelengths of light to produce reactive oxygen species (ROS) that effectively disrupt microbial biofilms and destroy resistant organisms. This review discusses the mechanism of action, efficacy against resistant strains, clinical applications, and future perspectives of aPDT in endodontics. Comparative insights with sodium hypochlorite, calcium hydroxide, and laser-based disinfection methods are highlighted. With its advantages of broad-spectrum antimicrobial activity, low cytotoxicity, and absence of microbial resistance, aPDT represents an innovative approach to enhance disinfection outcomes in endodontic therapy.
Keywords	Antimicrobial Photodynamic Therapy, aPDT, Endodontic Disinfection, Resistant Infections, Biofilms, Lasers
Field	Medical / Pharmacy
Published In	Volume 7, Issue 5, September-October 2025
Published On	2025-09-20
DOI	https://doi.org/10.36948/ijfmr.2025.v07i05.56161

About IJFMR Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us		+91-9687-828-838	editor@ijfmr.com

International Journal For Multidisciplinary Research