International Journal For Multidisciplinary Research

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Immunomodulatory Response in Rattus novergicus Rats Fed Biovina Mix Nano Technology Supplement Made from Gambier and Pasote Raw Materials

Author(s) Prof. Dr. Dingse Pandiangan, Dr. Nelson Nainggolan, Apt. Paulina Yolanda Yamlean, Prof. Dr. Readsway Truman Douglas Maramis, Apt. Michael Vallery Loueis Tumbol
Country Indonesia
Abstract Research has been conducted on immunomodulatory responses in rattus novergicus rats who were given biovina mix nanotechnology supplements ad libitum made from gambier and pasote raw materials. This study aims to see the effect of biovina supplementation on SOD, Catalase and IgG Serum levels as immunomodulatory indicators. The methods that are carried out in stages are rat rearing, treatment, rat blood collection, serum / blood centrifugation then IgG determination by ELISA method, SOD determination using Rat Super Oxidase Dismutase ELISA KIT, 96T, BT-LAB, cat. E0168Ra, and determination of catalase enzymes using the Catalase (CAT) Activity Assay Kit. The data was analyzed using the ANOVA method at a 95% confidence level. The results obtained were the highest levels in the Biovina Mix treatment without nano-studs, the highest IgG in the BM400-TD group of 5.57, the highest SOD in the BM800-TD group of 7.38, and the highest catalase in the BM800-TD group of 216.95. Based on the above, it can be concluded that nano-biovina has the potential to interact directly with free radicals formed after viral infection. This is possible because the viral load has not stimulated the increased inflammation that triggers the excessive production of free radicals. To evaluate the occurrence of inflammation after viral infection, it is necessary to perform a CRP test as an indicator of inflammation.
Keywords Immunomodulatory, Gambier, Pasote, Health Supplements
Field Biology > Medical / Physiology
Published In Volume 7, Issue 5, September-October 2025
Published On 2025-10-04
DOI https://doi.org/10.36948/ijfmr.2025.v07i05.57163
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