International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Comprehensive Review on Oral Hypoglycemic Agents in Geriatric Diabetic Patients

Author(s) Fathimath Nahana KT, Danisha P
Country India
Abstract Type 2 diabetes mellitus prevalence in the geriatric population continues to riseglobally, presenting unique therapeutic challenges due to age-related physiological changes, comorbidities, and polypharmacy, prompting a comprehensive literature review using PubMed, Cochrane Library, and EMBASE databases focusing on studies published between 2015-2024 involving geriatric patients with T2DM and oral antidiabetic medications to examine the efficacy, safety profiles, drug interactions, and evidence-based recommendations for clinical practice of oral hypoglycemic agents in this population. Current evidence supports individualized treatment approaches in geriatric patients, with metformin remaining first-line therapy when tolerated, while newer agents like DPP-4 inhibitors and SGLT-2 inhibitors show promise with improved safety profiles, and traditional agents like sulfonylureas require careful monitoring due to hypoglycemia risk, ultimately demonstrating that management of T2DM in geriatric patients requires a patient-centered approach that balances glycemic control with safety considerations and quality of life through regular monitoring and dose adjustments for optimal outcomes.
Keywords Geriatric diabetes, oral hypoglycemic agents, elderly patients, type 2 diabetes mellitus, pharmacotherapy
Field Medical / Pharmacy
Published In Volume 7, Issue 5, September-October 2025
Published On 2025-10-25
DOI https://doi.org/10.36948/ijfmr.2025.v07i05.57351
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E-ISSN 2582-2160
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