Stimuli-Responsive Ocular Inserts for Sustained drug Delivery system

Rachna Akhand Giri; Abdul Rajik; Pankaj Kumar Prajapati; Gopal Chaudhry

doi:10.36948/ijfmr.2025.v07i06.57786

Stimuli-Responsive Ocular Inserts for Sustained drug Delivery system

Author(s)	Dr. Rachna Akhand Giri, Mr. Abdul Rajik, Mr. Pankaj Kumar Prajapati, Mr. Gopal Chaudhry
Country	India
Abstract	Stimuli-responsive ocular inserts are a new way to deliver medicine over time for treating eye diseases. These inserts are made from special materials that change how they release medicine based on signals from the body, like changes in pH, temperature, or the presence of certain ions in the eye. These inserts can adjust how much medicine they give out as needed, which helps make sure the right amount is delivered for a longer time. This method also helps reduce side effects that might happen if the medicine goes into the rest of the body. The study describes a new type of insert that uses a special type of gel that reacts to changes in pH and contains drugs that help reduce inflammation, which is useful for treating long-term eye inflammation called chronic uveitis.The inserts were designed to break down slowly, releasing the medicine when it senses the acidic environment around inflamed eye tissues. Tests done in a lab showed that the medicine was released steadily over 14 days, with 80% of it coming out when the pH was 6.5, which is more acidic, compared to almost no release at a normal, neutral pH. Tests on how safe the inserts are showed that they don’t harm the cells on the surface of the eye. When tested in a model that mimics the eye, the medicine stayed longer in the front part of the eye. This system that controls itself could be a great way to tailor eye treatments for individuals, making it easier for patients to follow their treatment plans and leading to better results by needing fewer doses. Ocular treatments include medicines like eye drops and ointments, surgeries like LASIK and cataract surgery, and other treatments such as vision therapy and light therapy. These are used to treat conditions like glaucoma, cataracts, and refractive errors. Their goal is to help restore, improve, or keep the eye healthy and functioning properly.
Keywords	Stimuli-responsive, ocular inserts, controlled drug release, pH- sensitive, chronic uveitis, inflammation, biodegradable gel, sustained delivery, eye treatment, personalized medicine.
Field	Medical / Pharmacy
Published In	Volume 7, Issue 6, November-December 2025
Published On	2025-11-09
DOI	https://doi.org/10.36948/ijfmr.2025.v07i06.57786

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Stimuli-Responsive Ocular Inserts for Sustained drug Delivery system

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